The endothelium: a new target for therapy
The endothelium: a new target for therapy
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DOI：
10.1177/1358836x0000500108
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发表时间：
2000-02-01
影响因子：
3.5
通讯作者：
Cooke, JP
中科院分区：
文献类型：
--
作者：
Cooke, JP
内皮一度被认为只是血管导管内衬的单层细胞，但最近已成为一种功能与体内任何器官一样复杂的器官。内皮细胞是高度活跃的调节器官，可感知和评估情绪不断暴露的血流动力学、体液和炎症信号，并通过分泌影响血管张力和结构的因子做出反应。这些互动不仅仅是学术兴趣。人们越来越认识到内皮功能障碍在动脉粥样硬化和冠状动脉疾病的发生和进展中起着关键作用。
At one time considered merely a monolayer of cells lining the vascular conduit, the endothelium has emerged recently as an organ with functions as complex as any in the body. A highly active regulatory organ, the endothelium senses and assesses the hemodynamic, humoral, and inflammatory signals to which it is constantly exposed by the Mood and responds by secreting factors that affect vessel tone and structure. These interactions are not merely of academic interest. It has been increasingly recognized that endothelial dysfunction plays a pivotal role in the development and progression of atherosclerosis and coronary artery disease.