Working-memory training: effects on delay discounting in male Long Evans rats.
Working-memory training: effects on delay discounting in male Long Evans rats.
复制标题
工作记忆训练：对雄性长埃文斯大鼠延迟贴现的影响。
DOI：
10.1002/jeab.115
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发表时间：
2015
影响因子：
2.7
通讯作者：
Madden,GregoryJ
中科院分区：
文献类型：
--
作者：
Renda,CRenee;Stein,JeffreyS;Madden,GregoryJ
延迟折扣描述了奖励的贬值，因为收到奖励的延迟时间增加了。由于延迟折扣与许多行为问题（如物质依赖、赌博）密切相关，并且一些证据表明，在人类和大鼠中，延迟折扣先于并预示着药物服用，因此本研究试图通过实验减少大鼠的延迟折扣。据报道，与假训练组相比，接受工作记忆训练的人类兴奋剂依赖者的折扣率降低了（Bickel, Yi, Landes, Hill, & Baxter, 2011）。为了评估这种效应的跨物种普遍性，38只雄性Long - Evans大鼠被随机分配接受140次工作记忆训练或假训练（不需要记忆样本刺激），这些大鼠在训练前的延迟折现率上匹配。训练后的工作记忆组间差异较大；然而，训练后延迟折现率在各组间无差异。对这些发现的可能解释进行了讨论。
Delay discounting describes the devaluation of a reward as the delay to the receipt of the reward increases. Because steep delay discounting is robustly correlated with a number of behavioral problems (e.g., substance dependence, gambling) and some evidence suggests steep discounting precedes and predicts drug‐taking in humans and rats, this study sought to experimentally reduce rats' delay discounting. Human stimulant‐dependent participants given working‐memory training reportedly decreased their rates of discounting relative to a sham‐training group (Bickel, Yi, Landes, Hill, & Baxter, 2011). To evaluate the cross‐species generality of this effect, 38 male Long‐Evans rats, matched on pretraining delay‐discounting rates, were randomly assigned to receive 140 sessions of working‐memory training or sham training (which required no memory of the sample stimulus). Large between‐group differences in working memory were observed after training; however, posttraining delay‐discounting rates were undifferentiated across groups. Potential explanations for these findings are discussed.