KAI1, A METASTASIS SUPPRESSOR GENE FOR PROSTATE-CANCER ON HUMAN-CHROMOSOME 11P11.2
KAI1, A METASTASIS SUPPRESSOR GENE FOR PROSTATE-CANCER ON HUMAN-CHROMOSOME 11P11.2
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DOI：
10.1126/science.7754374
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发表时间：
1995-05-12
期刊：
影响因子：
56.9
通讯作者：
BARRETT, JC
中科院分区：
文献类型：
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作者：
DONG, JT;LAMB, PW;BARRETT, JC
从人染色体11p11.2中分离出一个基因，当导入大鼠AT 6.1前列腺癌细胞时，该基因显示出抑制转移。这种基因的表达，指定KAI 1，减少在人类细胞系来源于转移性前列腺肿瘤。KAI 1是一种由267个氨基酸组成的蛋白质，具有4个疏水性的跨膜结构域和1个大的胞外亲水性结构域，该结构域具有3个潜在的N-糖基化位点。KAI 1在进化上是保守的，在许多人体组织中表达，并编码白细胞表面糖蛋白的结构不同家族的成员。该基因表达的降低可能与前列腺癌和其他癌症的恶性进展有关。
A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.