Calculation of the reflection coefficient from measurements of endogenous vascular indicators.
Calculation of the reflection coefficient from measurements of endogenous vascular indicators.
复制标题
根据内源性血管指标的测量计算反射系数。
DOI：
10.1152/jappl.1988.64.4.1746
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Pilati,CF
中科院分区：
文献类型：
--
作者：
Maron,MB;Pilati,CF
总蛋白的溶剂阻力反射系数（σ）可以通过比较在分离的灌注器官中的流体过滤期间发生的红细胞和血浆蛋白的相对浓度程度来估计。在这个分析中，我们评估了Pilati和Maron [Am. J. Physiol.247（Heart Circ. 16）：H1-H7，1984]和Wolf等人[Am. J. Physiol.253（Heart Circ. Physiol.22）：H194-H204，1987]，以从这些浓度变化计算σ。我们使用从具有已知西格玛的膜中的流体和溶质通量的数学模型生成的数据来计算每个方程的西格玛。我们发现，Wolf等人的方程在测试的整个滤过分数范围内（0.1-0.6）提供了最接近真实σ的近似值，两个方程之间的差异随着滤过分数的增加而增加。在低过滤分数下，发现使用任一方法获得的σ差异是无关紧要的。在更大的过滤分数下，可以使用Wolf等人的方程获得真实σ的更接近的近似值。
The solvent drag reflection coefficient (sigma) for total proteins can be estimated by comparing the relative degrees of concentration of erythrocytes and plasma proteins that occur during fluid filtration in an isolated perfused organ. In this analysis, we evaluated the accuracy of equations proposed by Pilati and Maron [Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H1-H7, 1984] and Wolf et al. [Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H194-H204, 1987] to calculate sigma from these concentration changes. We calculated sigma with each equation using data generated from a mathematical model of fluid and solute flux in membranes with known sigma's. We found that the equation of Wolf et al. provided the closest approximation to the true sigma over the entire range of filtration fractions tested (0.1-0.6), with the differences between the two equations increasing with filtration fraction. At low filtration fractions, the difference in sigma obtained using either approach was found to be inconsequential. At larger filtration fractions, a closer approximation of the true sigma can be obtained using the equation of Wolf et al.