Molecular aspects of age-related cognitive decline: the role of GABA signaling.
Molecular aspects of age-related cognitive decline: the role of GABA signaling.
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DOI：
10.1016/j.molmed.2015.05.002
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发表时间：
2015-07
影响因子：
13.6
通讯作者：
Bizon JL
中科院分区：
文献类型：
--
作者：
McQuail JA;Frazier CJ;Bizon JL
抑制性中间神经元的改变导致与几种精神和神经疾病相关的认知缺陷。由γ-氨基丁酸（GABA）受体赋予的阶段性和紧张性抑制调节神经活动，并有助于在支持正常认知的皮层回路中建立适当的网络动力学。这篇综述强调了基础科学，证明抑制信号在衰老中发生了变化，并讨论了与年龄相关的抑制变化对不同形式的记忆功能的影响，包括大脑皮层依赖的空间参考记忆和前额叶皮层（PFU）依赖的工作记忆。临床适当性和易处理性选择治疗候选人的认知老化的目标受体介导的抑制也进行了讨论。
Alterations in inhibitory interneurons contribute to cognitive deficits associated with several psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ-amino-butyric acid (GABA) receptors regulates neural activity and helps to establish the appropriate network dynamics in cortical circuits that support normal cognition. This review highlights basic science demonstrating that inhibitory signaling is altered in aging, and discusses the impact of age-related shifts in inhibition on different forms of memory function, including hippocampus-dependent spatial reference memory and prefrontal cortex (PFU)-dependent working memory. The clinical appropriateness and tractability of select therapeutic candidates for cognitive aging that target receptors mediating inhibition are also discussed.