Targeting Deubiquitinating Enzymes (DUBs) That Regulate Mitophagy via Direct or Indirect Interaction with Parkin.
Targeting Deubiquitinating Enzymes (DUBs) That Regulate Mitophagy via Direct or Indirect Interaction with Parkin.
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DOI：
10.3390/ijms232012105
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发表时间：
2022-10-11
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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The quality control of mitochondria is critical for the survival of cells, and defects in the pathways required for this quality control can lead to severe disease. A key quality control mechanism in cells is mitophagy, which functions to remove damaged mitochondria under conditions of various stresses. Defective mitophagy can lead to a number of diseases including neurodegeneration. It has been proposed that an enhancement of mitophagy can improve cell survival, enhance neuronal function in neurodegeneration and extend health and lifespans. In this review, we highlight the role of deubiquitinating enzymes (DUBs) in the regulation of mitophagy. We summarise the current knowledge on DUBs that regulate mitophagy as drug targets and provide a list of small molecule inhibitors that are valuable tools for the further development of therapeutic strategies targeting the mitophagy pathway in neurodegeneration.
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影响因子：
6
作者：
Bello AI;Goswami R;Brown SL;Costanzo K;Shores T;Allan S;Odah R;Mohan RD
通讯作者：
Mohan RD
影响因子：
3.5
作者：
Cornelissen, Tom;Haddad, Dominik;Vandenberghe, Wim
通讯作者：
Vandenberghe, Wim
DOI：
10.1073/pnas.1608644113
发表时间：
2016-08-09
影响因子：
11.1
作者：
Braten, Ori;Livneh, Ido;Ciechanover, Aaron
通讯作者：
Ciechanover, Aaron
影响因子：
3.4
作者：
Colombo, Matteo;Vallese, Stefania;Guedat, Philippe
通讯作者：
Guedat, Philippe
影响因子：
64.8
作者：
Bingol, Baris;Tea, Joy S.;Sheng, Morgan
通讯作者：
Sheng, Morgan