Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: A meta-analysis of randomized. controlled trials
Chinese herbal medicine and interferon in the treatment of chronic hepatitis B: A meta-analysis of randomized. controlled trials
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DOI：
10.2105/ajph.92.10.1619
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发表时间：
2002-10-01
影响因子：
12.7
通讯作者：
Colford, JM
中科院分区：
文献类型：
--
作者：
McCulloch, M;Broffman, M;Colford, JM
目标。本荟萃分析旨在检验中草药（单独使用或与干扰素α联合使用）治疗慢性乙型肝炎的有效性。方法。我们检索了 TCMLARS、AMED、CISCOM、EMBASE、MEDLINE 和 Cochrane Collaboration 数据库，然后手动检索了文章的参考书目。结果。中草药显着增加 HBsAg 血清复归，且 HBeAg 和乙型肝炎病毒 (HBV) DNA 血清复归与干扰素 α 相当；中草药联合干扰素α显着增加HBsAg、HBeAg和HBV DNA的血清复归。中草药活性成分蟾蜍毒素联合干扰素α可显着提高HBeAg和HBV DNA血清逆转。中草药活性成分黑灵酮在HBeAg和HBV DNA血清复归方面与干扰素α相当。结论。尽管现有研究的质量较差，但这些数据表明，中草药和干扰素在慢性乙型肝炎感染中的进一步试验是合理的。
Objectives. This meta-analysis was conducted to examine the effectiveness of Chinese herbal medicine (either alone or with interferon alfa) in treating chronic hepatitis B.Methods. We searched the TCMLARS, AMED, CISCOM, EMBASE, MEDLINE, and Cochrane Collaboration databases and then hand-searched the articles' bibliographies.Results. Chinese herbal medicine significantly increased seroreversion of HBsAg and was equivalent to interferon alfa in seroreversion of HBeAg and hepatitis B virus (HBV) DNA; Chinese herbal medicine combined with interferon alfa significantly increased seroreversion of HBsAg, HBeAg, and HBV DNA. The Chinese herbal medicine active component bufotoxin combined with interferon alfa significantly increased HBeAg and HBV DNA seroreversion. The Chinese herbal medicine active component kurorinone was equivalent to interferon alfa in seroreversion of HBeAg and HBV DNA.Conclusions. Although the quality of existing studies was poor, these data suggest that further trials of Chinese Herbal Medicine and interferon in chronic hepatitis B infection are justified.