Effects of the menopause transition and hormone use on cognitive performance in midlife women
Effects of the menopause transition and hormone use on cognitive performance in midlife women
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DOI：
10.1212/wnl.0b013e3181a71193
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发表时间：
2009-05-26
期刊：
影响因子：
9.9
通讯作者：
Karlamangla, A. S.
中科院分区：
文献类型：
--
作者：
Greendale, G. A.;Huang, M. -H.;Karlamangla, A. S.
背景资料：几乎没有关于绝经过渡期（MT）认知表现的纵向信息：我们研究了2,362名来自全国妇女健康研究的参与者，为期4年。主要的暴露是在MT阶段花费的时间，最后一次月经前使用激素，以及绝经后目前使用激素。结果是三个领域的纵向表现：处理速度（符号数字模式测试[SDMT]），言语记忆（东波士顿记忆测试[EBMT]）和工作记忆（数字跨度向后）。
Background: There is almost no longitudinal information about measured cognitive performance during the menopause transition (MT).Methods: We studied 2,362 participants from the Study of Women's Health Across the Nation for 4 years. Major exposures were time spent in MT stages, hormone use prior to the final menstrual period, and postmenopausal current hormone use. Outcomes were longitudinal performance in three domains: processing speed (Symbol Digit Modalities Test [SDMT]), verbal memory (East Boston Memory Test [EBMT]), and working memory (Digit Span Backward).Results: Premenopausal, early perimenopausal, and postmenopausal women scored higher with repeated SDMT administration (p