Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments.
Converging models of schizophrenia--Network alterations of prefrontal cortex underlying cognitive impairments.
复制标题
DOI：
10.1016/j.pneurobio.2015.09.010
复制
发表时间：
2015-11
影响因子：
6.7
通讯作者：
Sawa A
中科院分区：
文献类型：
--
作者：
Sakurai T;Gamo NJ;Hikida T;Kim SH;Murai T;Tomoda T;Sawa A
前额叶皮质（PFC）及其与其他大脑区域的连接对于认知功能至关重要。认知障碍是与精神分裂症相关的核心症状之一，甚至在疾病发作之前就表现出来了。涉及PFC的改变的神经网络有助于精神分裂症的认知障碍。遗传和环境风险因素都会影响PFC内局部电路的发展以及更广泛的大脑网络的发展，并使该系统在青春期容易受到进一步的伤害，导致成年后的疾病发作。由于备用的认知功能与功能结果和预后相关，更好地了解认知障碍的机制将对精神分裂症的新型治疗方法具有重要意义。从基础神经科学到临床研究，需要多学科的方法来连接分子，电路，网络和行为表型。通过在连接体、行为读出和其他概念上共享共同语言，这些领域之间的密切互动对于实现这一目标至关重要。
The prefrontal cortex (PFC) and its connections with other brain areas are crucial for cognitive function. Cognitive impairments are one of the core symptoms associated with schizophrenia, and manifest even before the onset of the disorder. Altered neural networks involving PFC contribute to cognitive impairments in schizophrenia. Both genetic and environmental risk factors affect the development of the local circuitry within PFC as well as development of broader brain networks, and make the system vulnerable to further insults during adolescence, leading to the onset of the disorder in young adulthood. Since spared cognitive functions correlate with functional outcome and prognosis, a better understanding of the mechanisms underlying cognitive impairments will have important implications for novel therapeutics for schizophrenia focusing on cognitive functions. Multidisciplinary approaches, from basic neuroscience to clinical studies, are required to link molecules, circuitry, networks, and behavioral phenotypes. Close interactions among such fields by sharing a common language on connectomes, behavioral readouts, and other concepts are crucial for this goal.