Circadian Clocks and Metabolism: Implications for Microbiome and Aging.

Circadian Clocks and Metabolism: Implications for Microbiome and Aging.
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DOI:
10.1016/j.tig.2017.07.010
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发表时间:
2017-10
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
FitzGerald GA
FitzGerald GA
中科院分区:
其他
文献类型:
--
作者:
Paschos GK;FitzGerald GA

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The circadian clock directs many aspects of metabolism to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding out of phase to the light schedule may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome and how they relate to aging.
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