Improving robustness of 3D multi-shot EPI by structured low-rank reconstruction of segmented CAIPI sampling for fMRI at 7T
Improving robustness of 3D multi-shot EPI by structured low-rank reconstruction of segmented CAIPI sampling for fMRI at 7T
复制标题
通过对 7T 功能磁共振成像分段 CAIPI 采样进行结构化低秩重建，提高 3D 多镜头 EPI 的鲁棒性
DOI：
10.1101/2021.08.19.457024
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Chen X
三维（3D）编码方法越来越多地被探索作为功能磁共振成像（fMRI）中二维（2D）多切片采集的替代方案，特别是在需要高各向同性分辨率的情况下。作为3D fMRI成像的主力，3D多激发EPI采集易受生理波动的影响，这可能引起激发间相位变化，从而降低可实现的tSNR，抵消3D编码的一些益处。这个问题在像7 T这样的超高场下可能特别成问题，这具有更严重的非共振效应。在这项工作中，我们的目标是提高时间稳定性的三维多拍摄EPI在7 T通过提高其鲁棒性拍摄间相位变化。提出了一种三维分段CAIPI采样轨迹（seg-CAIPI）和一种改进的基于Hankel结构低秩矩阵恢复的重建方法。仿真和活体实验结果表明，seg-CAIPI采样方案与结构化低秩重构相结合，可以有效地减小激发间生理波动引起的不必要的时间方差，从而提高fMRI三维多激发EPI的鲁棒性。
Three-dimensional (3D) encoding methods are increasingly being explored as alternatives to two-dimensional (2D) multi-slice acquisitions in fMRI, particularly in cases where high isotropic resolution is needed. 3D multi-shot EPI acquisition, as the workhorse of 3D fMRI imaging, is susceptible to physiological fluctuations which can induce inter-shot phase variations, and thus reducing the achievable tSNR, negating some of the benefit of 3D encoding. This issue can be particularly problematic at ultra-high fields like 7T, which have more severe off-resonance effects. In this work, we aim to improve the temporal stability of 3D multi-shot EPI at 7T by improving its robustness to inter-shot phase variations. We presented a 3D segmented CAIPI sampling trajectory (“seg-CAIPI”) and an improved reconstruction method based on Hankel structured low-rank matrix recovery. Simulation and in-vivo results demonstrate that the combination of the seg-CAIPI sampling scheme and the proposed structured low-rank reconstruction is a promising way to effectively reduce the unwanted temporal variance induced by inter-shot physiological fluctuations, and thus improve the robustness of 3D multi-shot EPI for fMRI.
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