The unique nature of mg2+ channels.
The unique nature of mg2+ channels.
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DOI：
10.1152/physiol.00019.2008
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Maguire ME
中科院分区：
文献类型：
--
作者：
Moomaw AS;Maguire ME
考虑到镁离子的生物丰度和重要性，关于运输镁离子的蛋白质、其机制以及它们在细胞内的生理作用的信息令人惊讶地缺乏。到目前为止，最具特性的镁离子通道是细菌蛋白CORA，存在于广泛的细菌物种中。CORA同源基因mrs2在所有真核生物中形成线粒体镁离子通道。从生理上讲，CORA参与了细菌的发病，而mrs2真核同源基因对细胞的生存是必不可少的。在细菌中广泛存在的第二个镁离子通道是镁E。它的真核同源物是SLC41家族的携带者。MgtE及其同系物的生理作用尚未确定。最近，细菌CorA和镁离子通道的晶体结构被解决，这是任何二价阳离子通道的第一个结构。由于镁离子独特的生物化学特性，这两种结构都是独一无二的，不同于任何其他通道或转运蛋白。尽管在结构上完全不同，但CorA和MgtE似乎都是通过通道胞液结构域中的多个镁离子结合位点以相似的方式进行门控的。这些位点实质上是胞内镁离子浓度的“传感器”。然而，关于这些通道的许多问题仍然存在，包括镁离子选择性的分子基础和它们的真核同源物的生理作用(S)。
Considering the biological abundance and importance of Mg2+, there is a surprising lack of information regarding the proteins that transport Mg2+, the mechanisms by which they do so, and their physiological roles within the cell. The best characterized Mg2+ channel to date is the bacterial protein CorA, present in a wide range of bacterial species. The CorA homolog Mrs2 forms the mitochondrial Mg2+ channel in all eukaryotes. Physiologically, CorA is involved in bacterial pathogenesis, and the Mrs2 eukaryotic homolog is essential for cell survival. A second Mg2+ channel widespread in bacteria is MgtE. Its eukaryotic homologs are the SLC41 family of carriers. Physiological roles for MgtE and its homologs have not been established. Recently, the crystal structures for the bacterial CorA and MgtE Mg2+ channels were solved, the first structures of any divalent cation channel. As befits the unique biological chemistry of Mg2+, both structures are unique, unlike that of any other channel or transporter. Although structurally quite different, both CorA and MgtE appear to be gated in a similar manner through multiple Mg2+ binding sites in the cytosolic domain of the channels. These sites essentially serve as Mg2+ “sensors” of cytosolic Mg2+ concentration. Many questions about these channels remain, however, including the molecular basis of Mg2+ selectivity and the physiological role(s) of their eukaryotic homologs.
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影响因子：
3.2
作者：
HMIEL, SP;SNAVELY, MD;MAGUIRE, ME
通讯作者：
MAGUIRE, ME
影响因子：
5.5
作者：
Goytain, Angela;Quamme, Gary A.
通讯作者：
Quamme, Gary A.
影响因子：
4.8
作者：
Kucharski, LM;Lubbe, WJ;Maguire, ME
通讯作者：
Maguire, ME
DOI：
10.1107/s1744309107032332
发表时间：
2007-08-01
影响因子：
0.9
作者：
Hattori, Motoyuki;Tanaka, Yoshiki;Nureki, Osamu
通讯作者：
Nureki, Osamu
影响因子：
11.6
作者：
Li, LG;Tutone, AF;Luan, S
通讯作者：
Luan, S