Cytokine profiles in maternal serum are candidates for predicting an optimal timing for the delivery in early‐onset fetal growth restriction
Cytokine profiles in maternal serum are candidates for predicting an optimal timing for the delivery in early‐onset fetal growth restriction
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母体血清中的细胞因子谱可用于预测早发性胎儿生长受限的最佳分娩时机
DOI：
10.1002/pd.5679
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发表时间：
2020
影响因子：
3
通讯作者：
Sekizawa Akihiko
中科院分区：
文献类型：
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作者：
Kawashima Akihiro;Oba Tomohiro;Yasuhara Rika;Sekiya Bunbu;Sekizawa Akihiko
目的我们检查患有早发性胎儿生长受限（FGR）的母亲的母体血清细胞因子谱是否与妊娠晚期取样后 2 周内的分娩相关。研究设计这项探索性前瞻性横断面研究总共包括 20 名患有早发性 FGR 的单胎胎儿和 31 名健康对照。对妊娠晚期母亲血清样本中的 23 种细胞因子进行了分析。结果 在 20 名早发 FGR 的胎儿中，14 名在采样后 2 周内分娩。多变量分析显示，母体血清中可溶性血管内皮生长因子受体-1 (sVEGFR-1) 和可溶性 CD40 配体 (sCD40L) 的浓度与早发 FGR 中 2 周内的分娩独立相关。在早发性 FGR 病例中，几乎所有母体血清细胞因子的浓度相似。当分娩发生在 2 周内时，母体血清 sVEGFR-1 浓度较高。仅在由于胎儿恶化而在 2 周内分娩的情况下才会引发母体血清 sCD40L 浓度。结论我们确定了两种生物标志物，一种是 FGR 特异性的，另一种取决于严重程度，它们是血管生成活动和炎症因子的重要组成部分。血清蛋白表达失衡可能对 FGR 的发病机制产生重大影响。
ObjectiveWe examined whether maternal serum cytokine profiles of mothers with early‐onset fetal growth restriction (FGR) were associated with delivery within 2 weeks after sampling during the third trimester.Study designThis exploratory prospective cross‐sectional study included a total of 20 singleton fetuses with early‐onset FGR and 31 healthy controls. Maternal serum samples during the early third trimester were analyzed for 23 cytokines.ResultsOf 20 fetuses with early‐onset FGR, 14 had delivery within 2 weeks after sampling. Multivariate analysis revealed that maternal serum concentrations of soluble vascular endothelial growth factor receptor‐1 (sVEGFR‐1) and soluble CD40 ligand (sCD40L) were independently associated with delivery within 2 weeks in early‐onset FGR. Among cases of early‐onset FGR, concentrations of almost all maternal serum cytokines were similar. Maternal serum sVEGFR‐1 concentrations were high when delivery occurred within 2 weeks. Maternal serum sCD40L concentrations were elicited only in cases in which delivery within 2 weeks occurred due to fetal deterioration.ConclusionWe identified two biomarkers, one specific for FGR and the other dependent on severity, that were significant components of angiogenic activities and inflammation factors. Imbalances in serum protein expression may have a substantial effect on the pathogenesis of FGR.