Controllability modulates the neural response to predictable but not unpredictable threat in humans.
Controllability modulates the neural response to predictable but not unpredictable threat in humans.
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DOI：
10.1016/j.neuroimage.2015.06.086
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发表时间：
2015-10-01
期刊：
影响因子：
5.7
通讯作者：
Knight DC
中科院分区：
文献类型：
--
作者：
Wood KH;Wheelock MD;Shumen JR;Bowen KH;Ver Hoef LW;Knight DC
压力恢复力部分是由我们预测和控制环境中威胁的能力介导的。因此，确定调节情绪反应的神经机制，可预测和可控的威胁可能会提供重要的新的洞察调解情绪功能障碍的恢复力的过程，并指导未来的发展，焦虑症的干预措施。为了更好地了解可预测性和可控性对人类与威胁相关的大脑活动的影响，两组健康志愿者在功能性磁共振成像（fMRI）期间参加了一项结合巴甫洛夫恐惧条件反射研究。威胁可预测性通过呈现令人厌恶的无条件刺激（UCS）来操纵，所述无条件刺激（UCS）之前是条件刺激（即，可预测的）或通过单独呈现UCS（即，不可预测）。与采用轭式恐惧条件反射程序的动物模型研究类似，一组（可控条件反射; CC）能够终止UCS，但另一组（不可控条件反射; UC）不能。与不可预测的威胁相比，背外侧前额叶皮层（PFC）、背内侧PFC、腹内侧PFC和后扣带回内的fMRI信号反应在可预测的威胁期间减少（即，UCS）。此外，腹内侧PFC和双侧海马内的威胁相关的活动减少，只有威胁是可预测的和可控的。这些发现提供了对威胁可预测性和可控性如何影响大脑区域活动的见解（即，腹内侧PFC和海马）参与情绪调节，并可能有重要的意义，更好地了解神经过程，调解情绪弹性的压力。
Stress resilience is mediated, in part, by our ability to predict and control threats within our environment. Therefore, determining the neural mechanisms that regulate the emotional response to predictable and controllable threat may provide important new insight into the processes that mediate resilience to emotional dysfunction and guide the future development of interventions for anxiety disorders. To better understand the effect of predictability and controllability on threat-related brain activity in humans, two groups of healthy volunteers participated in a yoked Pavlovian fear conditioning study during functional magnetic resonance imaging (fMRI). Threat predictability was manipulated by presenting an aversive unconditioned stimulus (UCS) that was either preceded by a conditioned stimulus (i.e., predictable) or by presenting the UCS alone (i.e., unpredictable). Similar to animal model research that has employed yoked fear conditioning procedures, one group (Controllable Condition; CC), but not the other group (Uncontrollable Condition; UC) was able to terminate the UCS. The fMRI signal response within the dorsolateral prefrontal cortex (PFC), dorsomedial PFC, ventromedial PFC, and posterior cingulate was diminished during predictable compared to unpredictable threat (i.e., UCS). In addition, threat-related activity within the ventromedial PFC and bilateral hippocampus was diminished only to threats that were both predictable and controllable. These findings provide insight into how threat predictability and controllability affects the activity of brain regions (i.e., ventromedial PFC and hippocampus) involved in emotion regulation, and may have important implications for better understanding neural processes that mediate emotional resilience to stress.