Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors
Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors
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DOI：
10.3389/fpsyt.2018.00629
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发表时间：
2018-11-30
影响因子：
4.7
通讯作者：
Zhang, Wencai
中科院分区：
文献类型：
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作者：
Zhang, Xiaoyu;Zhang, Jianxin;Zhang, Wencai
目的：探讨符合DSM-5最新诊断标准的创伤后应激障碍(PTSD)患者的灰质体积(GMV)变化及其与症状严重程度的相关性。方法：71名受试者根据《精神疾病诊断与统计手册》第5版将受试者分为创伤后应激障碍组(n=35)和创伤暴露对照组(n=36)。结果：与TEC组相比，PTSD组左侧颞中回(MTG)和右侧背内侧前额叶皮质(DmPFC)的GMV较大，而右侧颞极区(TP)的GMV较小。创伤后应激障碍DSM-5(PCL-5)评分与左侧MTG、右侧dmPFC GMV呈正相关，与左侧TP GMV呈负相关。结论：在地震暴露人群中，根据DSM-5诊断标准对创伤后应激障碍患者进行分类时，MTG、dmPFC和TP的GMV变化在组间比较中被检测到，并与症状严重程度相关。
Objective: To detect the changes of gray matter volume (GMV) and their correlation with severity of symptom in patients with post-traumatic stress disorder (PTSD) who were defined with updated DSM-5 diagnostic criteria.Method: 71 participants were assigned into PTSD group (n = 35) or trauma-exposed control (TEC) group (n = 36) with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Voxel-based morphometry analysis was used to detect alterations in GMV in the PTSD group.Results: We found that the PTSD group had larger GMV in the left middle temporal gyrus (MTG) and in the right dorsal medial prefrontal cortex (dmPFC), and smaller GMV in the region of the right temporal pole (TP) than the TEC group. We also found that PTSD Checklist for DSM-5 (PCL-5) scores correlated positively with the left MTG and right dmPFC GMV, and negatively with left TP GMV. These correlations were consistent with the findings of the between-group comparisons.Conclusions: GMV alterations in the MTG, dmPFC, and TP are detected in the group comparisons and correlated with symptom severity when classifying PTSD individuals according to DSM-5 diagnostic criteria within an earthquake-exposed population.