Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film
Time-resolved in situ ATR-IR observations of the process of sorption of water into a poly(2-methoxyethyl acrylate) film
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DOI：
10.1021/la0625998
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发表时间：
2007-03-27
期刊：
影响因子：
3.9
通讯作者：
Ozaki, Yukihiro
中科院分区：
文献类型：
--
作者：
Morita, Shigeaki;Tanaka, Masaru;Ozaki, Yukihiro
采用时间分辨原位衰减全反射红外光谱研究了生物相容性高分子聚（丙烯酸2-甲氧基乙酯）（PMEA）的吸水过程。在PMEA中发现了三种不同类型的水化水，即不冻结水、冻结结合水和冻结水，并在官能团水平上阐明了每种水化结构。即使在-100摄氏度也不会结晶的不冻水与PMEA的羰基具有CO中心点H-O型氢键相互作用。在低于0 ℃的加热过程中结晶的冷冻结合水与PMEA侧链末端的甲氧基部分相互作用。冻结水，其结晶类似于0摄氏度，具有大量的水状结构，具有O-H中心点中心点O-H氢键网络。从本研究中可以得出结论，PMEA侧链末端的甲氧基部分对PMEA的优异生物相容性起着重要作用。
A process of water sorption into a biocompatible polymer, poly(2-methoxyethyl acrylate) (PMEA), was investigated by time-resolved, in situ, attenuated total reflection infrared spectroscopy. Evidence for three different types of hydrated water in PMEA, that is, nonfreezing water, freezing bound water, and freezing water, were found. Each hydration structure was elucidated at the functional group level. Nonfreezing water, which never crystallizes, even at -100 degrees C, has a CO center dot center dot center dot H-O type of hydrogen bonding interaction with the carbonyl group of PMEA. Freezing bound water, which crystallizes in a heating process below 0 degrees C, interacts with the methoxy moiety in the PMEA side chain terminal. Freezing water, which crystallizes similar to 0 degrees C, has bulk-water-like structure with an O-H center dot center dot center dot O-H hydrogen bonds network. It has been concluded from the present study that the methoxy moiety in the PMEA side chain terminal plays an important role for the excellent biocompatibility of PMEA.