Visualization of the intracranial pressure and time burden in childhood brain trauma: What we have learnt one decade on with KidsBrainIT.
Visualization of the intracranial pressure and time burden in childhood brain trauma: What we have learnt one decade on with KidsBrainIT.
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儿童脑外伤中颅内压和时间负担的可视化：十年来我们通过 KidsBrainIT 学到的知识。
DOI：
10.1089/neu.2023.0254
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发表时间：
2024
影响因子：
4.2
通讯作者：
Kempen B
中科院分区：
文献类型：
--
作者：
Kempen B
首次在多中心、跨国 KidsBrainIT 联盟前瞻性收集的儿童创伤性脑损伤 (pTBI) 数据集中验证颅内压 (ICP) 剂量反应可视化图。前瞻性收集 104 名 pTBI 患者的每分钟 ICP 和平均动脉血压时间序列，并按 ICP 强度-持续时间发作进行分类。这些事件与 6 个月的格拉斯哥结果评分 (GOS) 相关，并以颜色编码的 ICP 剂量反应图显示。研究了脑血管反应性和脑灌注压（CPP）的影响。在新数据集上生成的 ICP 剂量反应图与之前发布的儿科图类似。这项研究证实，较高的 ICP 发作可以在较短的时间内耐受，并以近似指数的衰减曲线描绘出正关联区和负关联区。 ICP 在任何时间段内高于 20mm Hg 都与我们患者的不良预后相关。 ICP 10mm Hg 以上时，脑血管反应状态不影响其各自的转变曲线。无论 ICP 和持续时间如何，CPP 低于 50mm Hg 都是不可接受的，并且与较差的结果相关。 ICP 剂量反应图在新颖且独立的 pTBI 数据集中重现。在任何时间段内，ICP 高于 20 mm Hg 和 CPP 低于 50 mm Hg 均与较差的结果相关。这突出表明迫切需要降低床边使用的儿科 ICP 治疗阈值。
To validate the intracranial pressure (ICP) dose-response visualization plot for the first time in a novel prospectively collected pediatric traumatic brain injury (pTBI) data set from the multi-center, multi-national KidsBrainIT consortium. Prospectively collected minute-by-minute ICP and mean arterial blood pressure time series of 104 pTBI patients were categorized in ICP intensity-duration episodes. These episodes were correlated with the 6-month Glasgow Outcome Score (GOS) and displayed in a color-coded ICP dose-response plot. The influence of cerebrovascular reactivity and cerebral perfusion pressure (CPP) were investigated. The generated ICP dose-response plot on the novel data set was similar to the previously published pediatric plot. This study confirmed that higher ICP episodes were tolerated for a shorter duration of time, with an approximately exponential decay curve delineating the positive and negative association zones. ICP above 20 mm Hg for any duration in time was associated with poor outcome in our patients. Cerebrovascular reactivity state did not influence their respective transition curves above 10 mm Hg ICP. CPP below 50 mm Hg was not tolerated, regardless of ICP and duration, and was associated with worse outcome. The ICP dose-response plot was reproduced in a novel and independent pTBI data set. ICP above 20 mm Hg and CPP below 50 mm Hg for any duration in time were associated with worse outcome. This highlighted a pressing need to reduce pediatric ICP therapeutic thresholds used at the bedside.
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影响因子：
38.9
作者：
Guiza, Fabian;Depreitere, Bart;Meyfroidt, Geert
通讯作者：
Meyfroidt, Geert
患有慢性阶段创伤性脑损伤的青少年通过要点推理训练获得认知收益
影响因子：
3.4
作者：
Lori G. Cook;S. Chapman;A. Elliott;N. Evenson;Kami Vinton
通讯作者：
Kami Vinton
影响因子：
1.4
作者：
Wettervik, Teodor Svedung;Velle, Fartein;Hanell, Anders;Howells, Timothy;Nilsson, Pelle;Lewen, Anders;Enblad, Per
通讯作者：
Enblad, Per
影响因子：
38.9
作者：
A. Sigurtà;C. Zanaboni;K. Canavesi;G. Citerio;Luigi Beretta;N. Stocchetti
通讯作者：
N. Stocchetti
影响因子：
4.1
作者：
MARMAROU, A;ANDERSON, RL;JANE, JA
通讯作者：
JANE, JA