Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis
Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis
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DOI：
10.1016/s0197-4580(01)00318-9
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发表时间：
2002-05-01
影响因子：
4.2
通讯作者：
Ohtomo, K
中科院分区：
文献类型：
--
作者：
Abe, O;Aoki, S;Ohtomo, K
本研究的目的是利用近红外扩散张量成像（DTI）技术研究正常衰老过程中中枢神经系统的平均扩散系数（ADC）和各向异性分数（FA）的变化。我们研究了50名正常志愿者（30名男性，20名女性;平均年龄44.8 +/- 14.0;年龄范围，21-69岁），没有影响中枢神经系统的疾病。选择胼胝体的额、顶叶、白色质、豆状核、内囊后肢、丘脑、胚和压部进行观察。ADC值和FA值在男女、左右半球之间无显著性差异。随着年龄的增长，额白色质（P = 0.010）和豆状核（P = 0.022）的ADC值显著增加。随着年龄的增长，仅胼胝体前部的FA值显著下降（P < 0.001）。定量弥散张量分析与正常衰老相关，可能有助于评估正常的年龄相关变化，并作为与神经退行性疾病比较的标准。(C)2002年爱思唯尔科技有限公司All rights reserved.
The put-pose of this study is to elucidate changes in mean diffusivity (ADC) and fractional anisotropy (FA) using NIR diffusion tensor imaging (DTI) in the central nervous system during normal aging. We studied 50 normal volunteers (30 men, 20 women; mean age 44.8 +/- 14.0; age range, 21-69 years) without disorders affecting the central nervous system. The frontal, parietal, white matter, lentiform nucleus, posterior limb of internal capsule, thalamus, germ and splenium of the corpus callosum were selected for investigation. There was no significant difference in ADC or FA between male and female or between the right and left hemisphere, A significant ADC increase with advancing age was observed in frontal white matter (P = 0.010) and lentiform nucleus (P = 0.022). A significant FA decline vas found only in the genu of the corpus callosum (P < 0.001) with advancing age. Quantitative diffusion tensor analysis correlate with normal aging and may help in assessing normal age-related changes and serve as a standard for comparison with neurodegenerative disorders. (C) 2002 Elsevier Science Inc. All rights reserved.