Aquaporins in Respiratory System
Aquaporins in Respiratory System
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DOI：
10.1007/978-94-024-1057-0_7
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Bai, Chunxue
中科院分区：
文献类型：
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作者：
Song, Yuanlin;Wang, Linlin;Bai, Chunxue
水通道蛋白（Aquaporins, AQPs）是一种水通道蛋白，被认为有助于肺泡间隙的液体运输、气道湿化、胸膜液吸收和粘膜下腺分泌。本章我们主要关注AQP1、AQP2、AQP4和AQP5 4种AQPs在正常和疾病状态下在肺中的表达情况，并详细总结各种模型和转基因小鼠对AQPs功能的研究经验，以提高我们对AQPs在呼吸系统体液平衡中的作用的认识。已有研究表明，AQPs在不同肺部疾病的各种生理和病理生理条件中发挥重要作用。AQPs在肺部疾病中的确切作用尚不清楚，因此有必要继续努力阐明AQPs在肺部生理和病理生理过程中的作用。
Aquaporins (AQPs) are water channel proteins supposed to facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion. In this chapter, we mainly focus on the expression of 4 AQPs in the lungs which include AQP1, AQP2, AQP4 and AQP5 in normal and disease status, and the experience of AQPs function from various model and transgenic mice were summarized in detail to improve our understanding of the role of AQPs in fluid balance of respiratory system. It has been suggested that AQPs play important roles in various physiology and pathophysiology conditions of different lung diseases. There still remains unclear the exact role of AQPs in lung diseases, and thus continuous efforts on elucidating the roles of AQPs in lung physiological and pathophysilogical processes are warranted.