Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex
Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex
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DOI：
10.1016/j.molmet.2013.11.009
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发表时间：
2014-04-01
影响因子：
8.1
通讯作者：
Fritsche, Andreas
中科院分区：
文献类型：
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作者：
Heni, Martin;Kullmann, Stephanie;Fritsche, Andreas
FTO的变异是体重的最强遗传决定因素，最近被认为与食物刺激的神经处理受损有关。然而，这种大脑表达的基因是否会影响摄入后与食物相关的刺激的神经元处理仍不清楚。在这项研究中，24名参与者在两天分别摄入75克葡萄糖溶液或水后，分别在30分钟和120分钟进行了检查。进行视觉食物呈现时的功能磁共振成像(FMRI)。所有受试者都接受了FTO SNP rs8050136的基因分型。在对食物图片的BOLD反应中，受试者前额叶皮质的FTO基因型间存在显著差异(p=0.0017)，而在饮水和葡萄糖负荷后120min的反应中则没有发现差异。由于前额叶皮质在控制进食的抑制中起主要作用，我们认为FTO风险等位基因携带者的餐后活动减少是导致暴饮暴食和肥胖的原因之一。
Variation in FTO is the strongest genetic determinant of body weight and has recently been linked with impaired neural processing of food stimuli. However, whether this brain-expressed gene affects neuronal processing of food-related stimuli after ingestion is still poorly understood.In this study, twenty-four participants were examined before, 30 and 120 min after ingesting 75 g of glucose solution or water on two separate days. Functional magnetic resonance imaging (fMRI) during visual food presentation was performed. All participants were genotyped for FTO SNP rs8050136.We detected significant differences between FTO genotypes in the prefrontal cortex 30 min post-glucose load in BOLD-response to food pictures (p=0.0017), while no differences were detected in response to water ingestion or 120 min post-glucose load.Since the prefrontal cortex plays a major role in the inhibitory control of eating, we propose that reduced postprandial activity in FTO risk allele carriers contributes to overeating and obesity.