Pancreatic cancer stroma: friend or foe?
Pancreatic cancer stroma: friend or foe?
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DOI：
10.1016/j.ccr.2014.05.026
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发表时间：
2014-06-16
期刊：
影响因子：
50.3
通讯作者：
Korc M
中科院分区：
文献类型：
--
作者：
Gore J;Korc M
胰腺癌的结缔组织增生被认为具有生物侵袭性。在这一期的《癌症细胞》杂志上，Özdemir和他的同事以及Rhim及其同事证明，靶向间质导致未分化的侵袭性胰腺癌，对检查点阻断或抗血管生成治疗有反应，揭示了间质在这种癌症中的保护作用。
Pancreatic cancer desmoplasia is thought to confer biological aggressiveness. In this issue of Cancer Cell, Özdemir and colleagues and Rhim and colleagues demonstrate that targeting the stroma results in undifferentiated, aggressive pancreatic cancer that responds to checkpoint blockade or antiangiogenic therapy, uncovering a protective role by stroma in this cancer.