Clinical significance of all-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury
Clinical significance of all-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury
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DOI：
10.1089/neu.2006.003789
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发表时间：
2007-02-01
影响因子：
4.2
通讯作者：
Hayes, Ronald L.
中科院分区：
文献类型：
--
作者：
Pineda, Jose A.;Lewis, Stephen B.;Hayes, Ronald L.
在创伤性脑损伤（TBI）后，细胞骨架蛋白α - ii -spectrin被calpain和caspase-3蛋白水解成特征分解产物。为了确定α - ii -spectrin蛋白水解是否是人类TBI的潜在可靠生物标志物，本研究(1)检测了严重TBI成人脑脊液（CSF）中spectrin分解产物（sbdp）的水平，(2)检测了这些水平与损伤严重程度和临床结果之间的关系。这项前瞻性病例对照研究纳入了41例严重TBI患者，由格拉斯哥昏迷量表（GCS）评分定义
Following traumatic brain injury (TBI), the cytoskeletal protein alpha-II-spectrin is proteolyzed by calpain and caspase-3 to signature breakdown products. To determine whether alpha-II-spectrin proteolysis is a potentially reliable biomarker for TBI in humans, the present study (1) examined levels of spectrin breakdown products (SBDPs) in cerebrospinal fluid (CSF) from adults with severe TBI and (2) examined the relationship between these levels, severity of injury, and clinical outcome. This prospective case control study enrolled 41 patients with severe TBI, defined by a Glasgow Coma Scale (GCS) score of