Thermochemotherapy of lower lip squamous cell carcinoma without metastases: An experience of 31 cases
Thermochemotherapy of lower lip squamous cell carcinoma without metastases: An experience of 31 cases
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无转移下唇鳞状细胞癌热化疗31例体会
DOI：
10.1016/j.jcms.2009.07.008
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发表时间：
2010-06-01
影响因子：
3.1
通讯作者：
Mao, Zu-yi
中科院分区：
文献类型：
--
作者：
Liang, Xin-hua;He, Yong-wen;Mao, Zu-yi
简介：本研究的目的是评估一种新的治疗方法，热化疗，无转移的下唇鳞状细胞癌（LLSCC）的疗效，功能和美学结果，和安全性。患者和方法：采用915 MHz微波局部热疗联合平阳霉素（盐酸博莱霉素A（5））和甲氨蝶呤（MTX）化疗治疗LLSCC 31例，每周2次，疗程4.5-7.5周。完全缓解（CR）的患者随访了整整5年，而部分缓解（PR）的患者被排除在外进行进一步分析。通过临床和影像学检查评估肿瘤的局部控制、功能和美容结局、复发、区域淋巴结和远处转移以及并发症。结果如下：临床完全缓解（CR）29例（93.55%），部分缓解（PR）2例（6.45%），总有效率100%，不良反应轻微，可耐受。所有29例CR（包括8例广泛病变）均获得了极好的外观和功能保留。在随访期间，1例局部复发，1例死亡，其余患者获得完全缓解。结论：这项临床研究表明，热化疗可能是一种可行的治疗原发性LLSCC无颈部转移，特别是对患者广泛的病变和妥协的一般条件。(C)2009年欧洲颅颌面外科协会
Introduction: The aim of this study was to evaluate the efficacy, functional and aesthetic results, and safety of a novel treatment, thermochemotherapy, for lower lip squamous cell carcinoma (LLSCC) without metastases. Patients and Methods: A combination of local hyperthermia delivered by a 915 MHz microwave heating system and the chemotherapy of pingyangmycin (bleomycin A(5) hydrochloride) (PYM) and methotrexate (MTX), was administered to 31 patients of LLSCC twice per week for a period of 4.5-7.5 weeks. Patients with complete response (CR) have been followed up for a full five-year period, whereas partial response (PR) patients were excluded for further analysis. The local control of tumour, functional and cosmetic outcomes, recurrence, regional lymph node and distant metastases, and complications were assessed by clinical and imaging examination. Results: Clinical CR was observed in twenty-nine (93.55%) patients and PR in two (6.45%), the total response rate was 100%, while the adverse effects were extremely minimal and tolerable in all 31 patients including 6 elderly patients with a compromised general condition. All 29 CR, including 8 extensive lesions, achieved excellent cosmetic and functional preservation. During the follow-up period, local relapse was seen in 1 case, 1 patient died, and the remainder obtained a complete remission. Conclusion: This clinical study suggests that thermochemotherapy may be a feasible treatment for primary LLSCC without cervical metastases, especially for patients with extensive lesions and a compromised general condition. (C) 2009 European Association for Cranio-Maxillo-Facial Surgery