Is Malignant Nodule Topography an Additional Risk Factor for Metastatic Disease in Low-Risk Differentiated Thyroid Cancer?
Is Malignant Nodule Topography an Additional Risk Factor for Metastatic Disease in Low-Risk Differentiated Thyroid Cancer?
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DOI：
10.1089/thy.2014.0217
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发表时间：
2014-11-01
期刊：
影响因子：
6.6
通讯作者：
Baldari, Sergio
中科院分区：
文献类型：
--
作者：
Campenni, Alfredo;Giovanella, Luca;Baldari, Sergio
背景：分化型甲状腺癌（DTC）是最常见的内分泌恶性肿瘤。近几十年来，发病率一直在增加，主要是由于低风险或极低风险DTC患者的检测增加。根据欧洲甲状腺协会和美国甲状腺协会指南，放射性碘（RAI）甲状腺残留消融不适用于极低风险患者，而其在低风险患者中的作用仍有争议。因此，在决定是否进行RAI消融时，DTC患者的风险分层是关键。目前，风险分层是基于pTNM分期与临床参数相结合。本研究的目的是评估甲状腺内恶性结节的位置与pT 1a-pT 1b DTC患者局部和/或远处转移的关系。方法：我们回顾了246例单灶性DTC患者（214例女性，32例男性;女性与男性的比例为6.7：1
Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. In recent decades, the incidence has been increasing, largely due to increased detection of patients with low-risk or very low-risk DTC. According to European Thyroid Association and American Thyroid Association guidelines, radioiodine (RAI) thyroid remnant ablation is not indicated in very low-risk patients, while its role is still debated in low-risk patients. Accordingly, risk stratification of DTC patients is pivotal when deciding for or against RAI ablation. Presently, risk stratification is based on pTNM staging integrated with clinical parameters. The aim of our study was to evaluate the relationship between location of malignant thyroid nodules within the thyroid gland and the presence of loco-regional and/or distant metastases in patients with pT1a-pT1b DTCs.Methods: We reviewed the records of 246 patients (214 women, 32 men; female-to-male ratio 6.7:1) affected by unifocal DTC