PLASMA RENIN ACTIVITY IN PRIMARY ALDOSTERONISM. IMPORTANCE IN DIFFERENTIAL DIAGNOSIS AND IN RESEARCH OF ESSENTIAL HYPERTENSION.
PLASMA RENIN ACTIVITY IN PRIMARY ALDOSTERONISM. IMPORTANCE IN DIFFERENTIAL DIAGNOSIS AND IN RESEARCH OF ESSENTIAL HYPERTENSION.
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原发性醛固酮增多症中的血浆肾素活性。
DOI：
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发表时间：
1964
期刊：
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通讯作者：
J. Conn
中科院分区：
文献类型：
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作者：
J. Conn
在前一份报告（第213页）中，对三个后来证实的原发性醛固酮增多症病例的详细研究最终表明，在存在醛固酮分泌肿瘤的情况下，血浆肾素活性被抑制到零，即使在严重缺钠多日后，血浆肾素活性也不能增加到零以上。使用相同的方法提取和测定肾素活性，建立了正常范围，从18个健康受试者在各种条件下研究。在所有病例中，各种强度的肾素活性都很容易测量，并且在限制钠72小时后，该值增加了两倍。2原发性醛固酮增多症中肾脏肾素释放的抑制不是由于高血醛固酮水平本身，而是由于血管内容量和压力的增加，这是已知的。4传入纤维压力感受器部位（肾小球细胞）的“拉伸“5增加
DETAILED STUDIES, in the preceding communication (p 213), on three subsequently proved cases of primary aldosteronism indicate conclusively that in the presence of an aldosterone-secreting tumor, plasma renin activity is suppressed to zero, and it cannot be increased above zero even after many days of severe sodium deprivation. Using the same method of extraction and assay for renin activity, a normal range was established from 18 healthy subjects studied under various conditions. In all cases renin activity of various intensities was easily measurable, and the values tripled upon restriction of sodium for 72 hours.2 The suppression of renal release of renin in primary aldosteronism is not due to a high blood level of aldosterone, per se, but rather to the increase in intravascular volume and pressure which is known to be associated with it.3,4The increase in "stretch"5at the baroreceptor site (juxtaglomerular cells) in the afferent