Relation of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy to Contractile Dysfunction Independent from Myocardial Injury
Relation of Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy to Contractile Dysfunction Independent from Myocardial Injury
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DOI：
10.1016/j.amjcard.2011.01.029
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发表时间：
2011-05-15
影响因子：
2.8
通讯作者：
van Rossum, Albert C.
中科院分区：
文献类型：
--
作者：
Timmer, Stefan A. J.;Germans, Tjeerd;van Rossum, Albert C.
我们研究了19例肥厚性心肌病（HC）患者充血心肌血流量（hMBF）、收缩功能和形态学组织改变之间的空间关系。所有患者均在休息和腺苷给药期间进行氧-15水正电子发射断层扫描以评估心肌灌注。进行心血管磁共振以获得延迟对比增强图像，并计算组织标记的收缩功能（E(cc)）。11名健康受试者接受了类似的正电子发射断层扫描和心血管磁共振扫描方案，并作为对照组。HC组hMBF平均为2.46 +/- 0.91 ml/min/g，平均E（cc）为-14.7 +/- 3.4%，分别低于对照组(3.97 +/- 1.48 ml/min/g和-17.7 +/- 3.2%,p
We studied the spatial relations among hyperemic myocardial blood flow (hMBF), contractile function, and morphologic tissue alterations in 19 patients with hypertrophic cardiomyopathy (HC). All patients were studied with oxygen-15 water positron emission tomography during rest and adenosine administration to assess myocardial perfusion. Cardiovascular magnetic resonance was performed to derive delayed contrast-enhanced images and to calculate contractile function (E(cc)) with tissue tagging. Eleven healthy subjects underwent similar positron emission tomographic and cardiovascular magnetic resonance scanning protocols and served as a control group. In the HC group, hMBF averaged 2.46 +/- 0.91 ml/min/g and mean E(cc) was -14.7 +/- 3.4%, which were decreased compared to the control group (3.97 +/- 1.48 ml/min/g and -17.7 +/- 3.2%, respectively, p