Rapid detection and destruction of squamous cell carcinoma of the head and neck by nano-quadrapeutics.
Rapid detection and destruction of squamous cell carcinoma of the head and neck by nano-quadrapeutics.
复制标题
通过纳米四极体快速检测和破坏头颈部鳞状细胞癌。
DOI：
10.1002/hed.24018
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Lapotko,DmitriO
中科院分区：
文献类型：
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作者：
Lukianova-Hleb,EkaterinaY;Lapotko,DmitriO
头颈鳞状细胞癌（HNSCC）患者无法安全完全切除，并形成耐药性残留和复发肿瘤，其生存率和生活质量仍然较差。我们报告了新颖的细胞级技术，quadrapeutics。 Quadrapeutics 将手术、药物和放射疗法转化为按需微治疗，通过使用 4 个标准组件将诊断和治疗结合在 1 个快速程序中：(1) 靶向金胶体； (2)脂质体药物； (3)激光脉冲； (4) 辐射，均处于安全剂量。四联治疗的治疗强度随着癌症侵袭性的增加而增加。在原发性和显微镜下残留 HNSCC 的动物模型中，quadrapeutics 仅使用临床剂量的 3% 至 6% 的药物和辐射，将标准放化疗的疗效提高了 17 倍以上，并且不会引起副作用，并且在术中检测到体内残留的微小肿瘤。 Quadrapeutics 可用于通过安全、快速的治疗诊断程序检测和根除 HNSCC 和类似的微肿瘤。 © 2015 Wiley periodicals, Inc.Head Neck37: 1547–1555, 2015
Survival and quality of life remain poor for patients with head and neck squamous cell carcinoma (HNSCC) that cannot be fully resected safely, and form therapy‐resistant residual and recurrent tumors. We report novel cell‐level technology, quadrapeutics. Quadrapeutics converts surgery, drug, and radiation therapies into on‐demand microtreatment that unites the diagnosis and treatment in 1 rapid procedure by using 4 standard components: (1) targeted gold colloids; (2) liposomal drugs; (3) a laser pulse; and (4) radiation, all at safe doses. The therapeutic strength of quadrapeutics increases with cancer aggressiveness. In animal models of a primary and microscopic residual HNSCC, quadrapeutics increased the efficacy of standard chemoradiation therapy by more than 17‐fold by using only 3% to 6% of clinical doses of drug and radiation, did not cause side effects, and detected residual microtumors in vivo intraoperatively. Quadrapeutics can be applied to detect and eradicate HNSCC and similar microtumors in a safe and rapid theranostic procedure. © 2015 Wiley Periodicals, Inc.Head Neck37: 1547–1555, 2015