Sympathetic neural responses to mental stress during acute simulated microgravity.
Sympathetic neural responses to mental stress during acute simulated microgravity.
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急性模拟微重力期间交感神经对精神压力的反应。
DOI：
10.1152/japplphysiol.00284.2009
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Carter,JasonR
中科院分区：
文献类型：
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作者：
Durocher,JohnJ;Schwartz,ChristopherE;Carter,JasonR
分别和联合检测了精神应激和急性6°头低位倾斜（HDT）的神经和心血管反应。我们假设交感神经兴奋在精神压力，交感神经抑制在HDT，和一个添加剂的神经相互作用在合并的精神压力和HDT。16名健康受试者（男8名，女8名）在3个随机试验中仰卧位记录了肌肉交感神经活动（MSNA）、平均动脉压（MAP）和心率（HR）：1）精神应激（心算法），2）卧床（HDT），3）精神应激和卧床（HDT）联合。精神应激显著增加MSNA（7 ± 1至12 ± 2次/min;P< 0.01）、MAP（91 ± 2至103 ± 2 mmHg;P< 0.01）和HR（70 ± 3至82 ± 3次/min;P< 0.01）。HDT不改变MSNA和HR，但MAP降低（91 ± 2 ~ 89 ± 3 mmHg，P< 0.05）。联合精神应激和HDT显著增加MSNA（7 ± 1至10 ± 1次/min;P< 0.01）、MAP（88 ± 3至99 ± 3 mmHg;P< 0.01）和HR（70 ± 3至82 ± 3次/min;P< 0.01）。联合试验期间MSNA和HR的增加与单独试验的总和无差异。然而，联合试验期间MAP的增加显著大于单独试验的总和（变化11 ± 1 vs. 9 ± 1 mmHg;P< 0.05）。我们的结论是，MSNA和HR的相互作用是加性的，在合并精神应激和HDT，但MAP反应略有增加，在合并试验。这些研究结果表明，交感神经对精神压力的反应不会因模拟微重力而改变。
Neural and cardiovascular responses to mental stress and acute 6° head-down tilt (HDT) were examined separately and combined. We hypothesized sympathoexcitation during mental stress, sympathoinhibition during HDT, and an additive neural interaction during combined mental stress and HDT. Muscle sympathetic nerve activity (MSNA), mean arterial pressure (MAP), and heart rate (HR) were recorded in 16 healthy subjects (8 men, 8 women) in the supine position during three randomized trials:1) mental stress (via mental arithmetic),2) HDT, and3) combined mental stress and HDT. Mental stress significantly increased MSNA (7 ± 1 to 12 ± 2 bursts/min;P< 0.01), MAP (91 ± 2 to 103 ± 2 mmHg;P< 0.01), and HR (70 ± 3 to 82 ± 3 beats/min;P< 0.01). HDT did not change MSNA or HR, but MAP was reduced (91 ± 2 to 89 ± 3 mmHg;P< 0.05). Combined mental stress and HDT significantly increased MSNA (7 ± 1 to 10 ± 1 bursts/min;P< 0.01), MAP (88 ± 3 to 99 ± 3 mmHg;P< 0.01), and HR (70 ± 3 to 82 ± 3 beats/min;P< 0.01). Increases in MSNA and HR during the combination trial were not different from the sum of the individual trials. However, the increase in MAP during the combination trial was significantly greater than the sum of the individual trials (change of 11 ± 1 vs. 9 ± 1 mmHg;P< 0.05). We conclude that the interaction for MSNA and HR are additive during combined mental stress and HDT but that MAP responses are slightly augmented during the combined trial. These findings demonstrate that sympathetic neural responses to mental stress are unaltered by simulated microgravity.