OPTIC-NERVE DAMAGE IN HUMAN GLAUCOMA .3. QUANTITATIVE CORRELATION OF NERVE-FIBER LOSS AND VISUAL-FIELD DEFECT IN GLAUCOMA, ISCHEMIC NEUROPATHY, PAPILLEDEMA, AND TOXIC NEUROPATHY
OPTIC-NERVE DAMAGE IN HUMAN GLAUCOMA .3. QUANTITATIVE CORRELATION OF NERVE-FIBER LOSS AND VISUAL-FIELD DEFECT IN GLAUCOMA, ISCHEMIC NEUROPATHY, PAPILLEDEMA, AND TOXIC NEUROPATHY
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DOI：
10.1001/archopht.1982.01030030137016
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
GREEN, WR
中科院分区：
文献类型：
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作者：
QUIGLEY, HA;ADDICKS, EM;GREEN, WR
将人类视神经轴突的数量和分布与同一只眼睛的临床测量结果进行比较，包括视力、视盘外观和视野研究。在一些怀疑患有青光眼的患者中，轴突的明确丢失发生在可复制的视野缺陷之前。在青光眼中，神经的上下两极选择性地以更快的速度丢失神经纤维，导致沙漏状萎缩。在慢性青光眼中，球后视神经的海绵状变性很少见。中毒性弱视、缺血性视神经病变和慢性乳头状肿的萎缩模式与青光眼不同，提示这些情况下的损害机制不同。
The number and distribution of human optic nerve axons were compared with clinical measurements available in the same eyes, including visual acuity, disc appearance, and visual field studies. Definite loss of axons occurs prior to reproducible visual field defects in some patients suspected of having glaucoma. In glaucoma the superior and inferior poles of the nerve lose nerve fibers at a selectively greater rate, leading to an hourglass-shaped atrophy. Cavernous degeneration of the retrobulbar optic nerve is rarely observed in chronic glaucoma. The pattern of atrophy in examples of toxic amblyopia, ischemic optic neuropathy, and chronic papilledema differs from that of glaucoma, suggesting different mechanisms of damage in these conditions.