Interleukin-2 Deficiency Associated with Renal Impairment in Systemic Lupus Erythematosus
Interleukin-2 Deficiency Associated with Renal Impairment in Systemic Lupus Erythematosus
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IL-2 缺乏与系统性红斑狼疮肾损伤相关
DOI：
10.1089/jir.2018.0016
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发表时间：
2019-02-01
影响因子：
2.3
通讯作者：
Li, Zhanguo
中科院分区：
文献类型：
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作者：
Shao, Miao;He, Jing;Li, Zhanguo
系统性红斑狼疮（SLE）患者白细胞介素-2（IL-2）产生受损。本研究旨在探讨血清IL-2水平与系统性红斑狼疮（SLE），特别是狼疮性肾炎（LN）的临床相关性及重组IL-2（rIL-2）的治疗作用。活动期LN患者血清IL-2水平明显降低（P = 0.014），且与24 h尿蛋白定量呈显著正相关（r =-0.281，P = 0.026）。血清IL-2水平升高的LN患者缓解率高于血清IL-2水平降低的LN患者（P = 0.041）。此外，外源性小剂量IL-2补充治疗的患者表现出更好的改善肾炎和更高的缓解率（55.56%，P = 0.058）比常规治疗。此外，在接受低剂量重组人IL-2治疗的LN患者中，调节性T（Treg）细胞百分比扩增（P = 0.007），尤其是在达到缓解的LN患者中（P = 0.010）。IL-2缺乏与肾损害相关，可通过外源性IL-2补充来改善。
Impaired interleukin-2 (IL-2) production was reported in systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical relevance of serum IL-2 and therapeutic effects of recombinant IL-2 (rIL-2) in SLE, especially in lupus nephritis (LN). Decreased serum IL-2 was found in patients with active LN (P = 0.014) and correlated with 24-h urine protein excretion (r = -0.281, P = 0.026). Compared with LN patients with decreased levels of serum IL-2, patients with increased levels had better remission rate (P = 0.041). Furthermore, patients with exogenous low-dose IL-2 supplement demonstrated better improved nephritis and higher remission rate (55.56%, P = 0.058) than those with conventional therapy. In addition, the percentages of regulator T (Treg) cells expanded in LN patients with low-dose recombinant human IL-2 treatment (P = 0.007), especially in LN patients achieving remission (P = 0.010). IL-2 deficiency is associated with renal impairment that can be improved by exogenous IL-2 supplement.