INFLAMMATION CAUSES HYPERPLASIA AND HYPERTROPHY IN SMOOTH-MUSCLE OF RAT SMALL-INTESTINE
INFLAMMATION CAUSES HYPERPLASIA AND HYPERTROPHY IN SMOOTH-MUSCLE OF RAT SMALL-INTESTINE
复制标题
DOI：
10.1152/ajpgi.1992.262.6.g1041
复制
发表时间：
1992-06-01
影响因子：
--
通讯作者：
COLLINS, SM
中科院分区：
文献类型：
--
作者：
BLENNERHASSETT, MG;VIGNJEVIC, P;COLLINS, SM
旋毛虫感染大鼠空肠后第6天（PI），炎症引起平滑肌收缩力改变。我们研究了平滑肌层结构变化与炎症的关系。感染后第6天，空肠纵、环肌层平滑肌面积增加（P < 0.05）。横截面中的细胞核计数显示，CM和LM中的细胞数量增加了2至3倍，并且这种增加在Pl第23天没有逆转。细胞大小的估计显示，在两个肌肉层中，PI第6天显著肥大。[H-3]胸腺嘧啶核苷放射自显影显示空肠LM和CM的标记指数（LI）在感染后第4天急剧增加，并在感染后第6天达到峰值（增加10至15倍）。非炎症回肠显示出较小的营养反应，面积或细胞核数量没有显着变化; LI增加，只有在第6天PI在回肠CM和LM不变。因此，平滑肌细胞的广泛增生和肥大与肠道炎症有关。
Inflammation of the rat jejunum with Trichinella spiralis causes altered smooth muscle contractility by day 6 postinfection (PI). We investigated the association of structural change in the smooth muscle layers with inflammation. By day 6 PI, smooth muscle area in cross sections of jejunum increased (P < 0.05) in longitudinal (LM) and circular (CM) muscle layers. Nuclei counting in cross sections showed that cell number increased two- to threefold in CM and LM, and this increase was not reversed on day 23 Pl. Estimation of cell size showed significant hypertrophy by day 6 PI in both muscle layers. [H-3]thymidine autoradiography showed that the labeling index (LI) of jejunal LM and CM increased sharply on day 4 PI and peaked on day 6 PI (10- to 15-fold increase). The noninflamed ileum showed a smaller trophic response, with no significant change in area or nuclei number; the LI was increased only on day 6 PI in the ileal CM and was unchanged in LM. Thus extensive hyperplasia and hypertrophy of smooth muscle cells are associated with intestinal inflammation.