Design and serendipity in establishing a large cohort with wide dietary intake distributions - The National Institutes of Health-American Association of Retired Persons Diet and Health Study
Design and serendipity in establishing a large cohort with wide dietary intake distributions - The National Institutes of Health-American Association of Retired Persons Diet and Health Study
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DOI：
10.1093/aje/154.12.1119
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发表时间：
2001-12-15
影响因子：
5
通讯作者：
Kipnis, V
中科院分区：
文献类型：
--
作者：
Schatzkin, A;Subar, AF;Kipnis, V
1995-1996年，作者向350万美国退休人员协会成员邮寄了一份食物频率问卷，这些成员年龄在50-69岁之间，居住在拥有高质量癌症登记的六个州或两个大都市地区之一。在建立567,169人(340,148名男性和227,021名女性)的队列中，作者的幸运之处在于，低于预期的基线应答率(威胁到极端摄入量的受访者人数不足)被提供令人满意数据的人中摄入量分布的变化和扩大所抵消。报告的第一和第五摄入量五分位数的中位数分别为来自脂肪的20.4%和40.1%(男性)和20.1%和40.0%(女性)，每日膳食纤维10.3%和32.0g(男性)和8.7g和28.7g，水果和蔬菜每天3.1g和11.6g(男性)和2.8g和11.3g，以及红肉每天20.7g和156.8克(男性)和10.5g(女性)和97.0g。经过5年的随访，该队列预计将产生近4,000例乳腺癌、10,000多例前列腺癌、4,000多例结直肠癌和900多例胰腺癌。队列的庞大规模和广泛的摄入范围将为检验一些重要的饮食和癌症假说提供充足的力量。
In 1995-1996, the authors mailed a food frequency questionnaire to 3.5 million American Association of Retired Persons members who were aged 50-69 years and who resided in one of six states or two metropolitan areas with high-quality cancer registries. In establishing a cohort of 567,169 persons (340,148 men and 227,021 women), the authors were fortunate in that a less-than-anticipated baseline response rate (threatening inadequate numbers of respondents in the intake extremes) was offset by both a shifting and a widening of the intake distributions among those who provided satisfactory data. Reported median intakes for the first and fifth intake quintiles, respectively, were 20.4 and 40.1 (men) and 20.1 and 40.0 (women) percent calories from fat, 10.3 and 32.0 (men) and 8.7 and 28.7 (women) g per day of dietary fiber, 3.1 and 11.6 (men) and 2.8 and 11.3 (women) servings per day of fruits and vegetables, and 20.7 and 156.8 (men) and 10.5 and 97.0 (women) g per day of red meat. After 5 years of follow-up, the cohort is expected to yield nearly 4,000 breast cancers, more than 10,000 prostate cancers, more than 4,000 colorectal cancers, and more than 900 pancreatic cancers. The large size and wide intake range of the cohort will provide ample power for examining a number of important diet and cancer hypotheses.