Type 2 diabetes mellitus and risk of non-Hodgkin lymphoma: A systematic review and meta-analysis
Type 2 diabetes mellitus and risk of non-Hodgkin lymphoma: A systematic review and meta-analysis
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DOI：
10.1093/aje/kwn160
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发表时间：
2008-09-01
影响因子：
5
通讯作者：
Page, John H.
中科院分区：
文献类型：
--
作者：
Chao, Chun;Page, John H.
2型糖尿病与免疫功能改变和慢性炎症有关。这两种免疫状况都与非霍奇金淋巴瘤的发病机制有关。作者进行了一项系统性综述，总结了当前文献中关于2型糖尿病病史与非霍奇金淋巴瘤风险之间关系的结果。本综述包括10项病例对照研究和3项前瞻性队列研究。荟萃分析发现，2型糖尿病史与总体非霍奇金淋巴瘤风险呈正相关。然而，研究之间存在显著异质性。研究设计是异质性的重要来源。在病例对照研究中，2型糖尿病与非霍奇金淋巴瘤的比率为1.18（95%置信区间：0.99，1.42），在前瞻性队列研究中为1.79（95%置信区间：1.30，2.47）。在病例和对照选择、协变量和非霍奇金淋巴瘤的测量以及混杂对照方面，在一些纳入的研究中发现了弱点。虽然2型糖尿病与非霍奇金淋巴瘤风险之间存在正相关，但由于纳入病例对照研究的方法学限制，证据尚不确定。需要更多的前瞻性研究来证实这些发现。
Type 2 diabetes mellitus is associated with altered immune function and chronic inflammation. Both of these immune conditions are implicated in the pathogenesis of non-Hodgkin lymphoma. The authors performed a systematic review to summarize findings from the current literature on the association between history of type 2 diabetes mellitus and risk of non-Hodgkin lymphoma. Ten case-control studies and three prospective cohort studies were included in this review. Meta-analysis found that a history of type 2 diabetes mellitus was positively associated with overall non-Hodgkin lymphoma risk. However, there was significant heterogeneity between studies. Study design was an important source of heterogeneity. The rate ratio between type 2 diabetes mellitus and non-Hodgkin lymphoma was found to be 1.18 (95% confidence interval: 0.99, 1.42) among case-control studies and 1.79 (95% confidence interval: 1.30, 2.47) among the prospective cohort studies. Weaknesses were identified in some of the included studies in the areas of case and control selection, measurement of covariates and non-Hodgkin lymphoma, and confounding control. Although a positive association between type 2 diabetes mellitus and risk of non-Hodgkin lymphoma was suggested, the evidence is inconclusive because of methodological limitations of the included case-control studies. More prospective studies with improved control of confounding are needed to confirm these findings.