Intravascular contrast media and the blood-brain barrier. Testing the new nonionic agent ioxilan.
Intravascular contrast media and the blood-brain barrier. Testing the new nonionic agent ioxilan.
复制标题
血管内造影剂和血脑屏障。
DOI：
10.1097/00004424-198901000-00009
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发表时间：
1989
影响因子：
6.7
通讯作者：
Mukherji,M
中科院分区：
文献类型：
--
作者：
Harnish,PP;Krutchen,A;Mukherji,M
在正常和高血压大鼠中研究了泛影酸盐、碘海醇和碘西兰对血脑屏障 (BBB) 的影响。麻醉的 Wistar 大鼠接受 14C-菊粉作为血脑屏障破坏的指示剂。然后将泛影酸盐、碘海醇或碘西兰（350 和 175 mgl/mL）或生理盐水注入颈动脉（30 秒内 2 mL）。二十分钟后，心血管系统被冲洗，大脑被取出，每个半球都被消化。通过方差分析对每组中每个半球的血脑屏障破坏进行比较，以计数/分钟/毫克蛋白质表示。泛影酸盐-350 组的 BBB 损伤明显大于所有其他组。相对于生理盐水，碘海醇或碘西兰没有造成明显的血脑屏障损伤。
The effects of diatrizoate, iohexol, and ioxilan on the blood-brain barrier (BBB) were investigated in normal and hypertensive rats. Anesthetized Wistar rats received 14C-inulin as an indicator for BBB disruption. Diatrizoate, iohexol, or ioxilan (350 and 175 mgl/mL) or normal saline was then injected into the carotid artery (2 mL in 30 seconds). Twenty minutes later, the cardiovascular system was flushed, the brain removed, and each hemisphere was digested. BBB disruption, expressed as counts/minute/mg protein, was compared for each hemisphere in each group by analysis of variance. BBB damage in the diatrizoate-350 group was significantly greater than that in all other groups. No significant BBB damage resulted from iohexol or ioxilan relative to normal saline.