Immunomodulation of periodontitis with SPMs.
Immunomodulation of periodontitis with SPMs.
复制标题
DOI：
10.3389/froh.2023.1288722
复制
发表时间：
2023
影响因子：
--
通讯作者：
Van Dyke, Thomas E
中科院分区：
文献类型：
--
作者：
Sahni, Vaibhav;Van Dyke, Thomas E
炎症是许多疾病过程的病理生理学中的关键组成部分，大多数治疗方式都侧重于抑制炎症以实现治疗结果。炎症的消退是一个单独的、独特的途径，需要将炎症过程逆转至体内平衡状态，而不是选择性抑制炎症级联反应的特定组分。专门的促消退介质（SPMs）的发现导致了我们对疾病病因学理解的范式转变。牙周病，传统上被认为是微生物病因之一，现在被理解为与口腔微生物组的生态失调相关的炎症驱动的过程，其可以用SPM调节以实现治疗益处。
Inflammation is a critical component in the pathophysiology of numerous disease processes, with most therapeutic modalities focusing on its inhibition in order to achieve treatment outcomes. The resolution of inflammation is a separate, distinct pathway that entails the reversal of the inflammatory process to a state of homoeostasis rather than selective inhibition of specific components of the inflammatory cascade. The discovery of specialized pro-resolving mediators (SPMs) resulted in a paradigm shift in our understanding of disease etiopathology. Periodontal disease, traditionally considered as one of microbial etiology, is now understood to be an inflammation-driven process associated with dysbiosis of the oral microbiome that may be modulated with SPMs to achieve therapeutic benefit.