Cytosine-gated hole creation and transfer in DNA in aqueous solution
Cytosine-gated hole creation and transfer in DNA in aqueous solution
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DOI：
10.1021/ja0658416
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发表时间：
2006-12-20
影响因子：
15
通讯作者：
Maroz, Andrej
中科院分区：
文献类型：
--
作者：
Anderson, Robert F.;Shinde, Sujata S.;Maroz, Andrej
亚硒酸盐自由基 SeO3- 被发现在双链 DNA 的单电子氧化时选择性地产生胞苷自由基。这首先是一个令人惊讶的结果，因为 SeO3- 只能氧化 DNA 碱基的鸟嘌呤，这意味着瞬时形成的鸟苷自由基阳离子必须在失去质子的情况下转变成中性胞苷自由基。观察到反氧化产生中性鸟苷自由基，与另一个固定反应竞争。
The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3-can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed.