In Vitro Sustained Release of Calcium Ions and pH Maintenance from Different Vehicles Containing Calcium Hydroxide
In Vitro Sustained Release of Calcium Ions and pH Maintenance from Different Vehicles Containing Calcium Hydroxide
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DOI：
10.1016/j.joen.2009.12.021
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发表时间：
2010-05-01
影响因子：
4.2
通讯作者：
Bhat, Kadengodlu Seetharama
中科院分区：
文献类型：
--
作者：
Ballal, Nidambur Vasudev;Shavi, Gopal Venktesh;Bhat, Kadengodlu Seetharama
简介：氢氧化钙是一种广泛应用于牙髓学的管内药物。它的治疗效果取决于氢氧化钙解离成钙离子和羟基离子，这反过来又取决于所使用的载体。本体外研究的目的是评价丙二醇、聚乙二醇6000、壳聚糖和瓜尔胶配制的氢氧化钙在30天内钙离子的缓释和pH值的变化。方法：制备各种制剂，置于人牙根管内，悬浮于装有蒸馏水的玻璃瓶中。在特定的时间间隔，用紫外分光光度计分析钙离子浓度。在长达30天的不同时间间隔内测量培养基的pH变化。结果：壳聚糖对钙离子的缓释效果优于其他3种剂型。所有配方在30天内均呈现高碱性pH值。结论：壳聚糖可作为根管内氢氧化钙钙离子缓释载体。[J] end2010;36:862-866。
Introduction: Calcium hydroxide is widely used as an intracanal medicament in endodontics. Its therapeutic effects depend on the dissociation of calcium hydroxide into calcium and hydroxyl ions, which, in turn, depends on the vehicle used. The purpose of this in vitro study was to evaluate the sustained release of calcium ions and the pH change of calcium hydroxide over a period of 30 days when formulated with propylene glycol, polyethylene glycol 6000, chitosan, and guar gum. Methods: Various formulations were prepared and placed inside the root canals of human teeth and were suspended in glass vials containing distilled water. At specific time intervals, the calcium ion concentration was analyzed using an ultraviolet spectrophotometer. pH changes of the medium were measured at various time intervals up to 30 days. Results: Results revealed that chitosan formulation showed the maximum sustained release of calcium ions compared with the other three formulations. All the formulations exhibited high alkaline pH upto 30 days. Conclusion: From the results of this in vitro study, it can be concluded that chitosan can be used as a promising vehicle for for the sustained release of calcium ions from the calcium hydroxide in the root canal system. (J Endod 2010;36:862-866)