CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways
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DOI：
10.1084/jem.20181308
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发表时间：
2019-12-01
影响因子：
15.3
通讯作者：
Kohlmeier, Jacob E.
中科院分区：
文献类型：
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作者：
Wein, Alexander N.;McMaster, Sean R.;Kohlmeier, Jacob E.
常驻记忆T细胞（T-RM细胞）是对抗呼吸道病原体的重要第一线防御，但肺T-RM细胞群对保护性免疫的独特贡献以及控制其定位于肺不同区室的因素尚未完全了解。在这里，我们表明，气道和间质T-RM细胞具有不同的效应功能，CXCR 6通过招募CD 8 T-RM细胞到气道来控制肺内T-RM细胞的分配。CXCR 6的缺乏由于肺内CXCR 6（-/-）细胞的改变的运输而显著减少气道CD 8 T RM细胞，并且不减少气道中的存活。CXCL 16是CXCR 6的配体，主要位于呼吸道上皮，缺乏CXCL 16的小鼠气道中的CD 8 T-RM细胞也减少。最后，阻断CXCL 16抑制气道T-RM细胞的稳态维持。因此，CXCR 6/CXCL 16信号传导轴控制T-RM细胞定位于肺的不同隔室并维持气道T-RM细胞。
Resident memory T cells (T-RM cells) are an important first-line defense against respiratory pathogens, but the unique contributions of lung T-RM cell populations to protective immunity and the factors that govern their localization to different compartments of the lung are not well understood. Here, we show that airway and interstitial T-RM cells have distinct effector functions and that CXCR6 controls the partitioning of T-RM cells within the lung by recruiting CD8 T-RM cells to the airways. The absence of CXCR6 significantly decreases airway CD8 T RM cells due to altered trafficking of CXCR6(-/-) cells within the lung, and not decreased survival in the airways. CXCL16, the ligand for CXCR6, is localized primarily at the respiratory epithelium, and mice lacking CXCL16 also had decreased CD8 T-RM cells in the airways. Finally, blocking CXCL16 inhibited the steady-state maintenance of airway T-RM cells. Thus, the CXCR6/CXCL16 signaling axis controls the localization of T-RM cells to different compartments of the lung and maintains airway T-RM cells.