Erythrocyte defects and parasitemia density in patients with Plasmodium falciparum malaria in Buenaventura, Colombia
Erythrocyte defects and parasitemia density in patients with Plasmodium falciparum malaria in Buenaventura, Colombia
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DOI：
10.1590/s1020-49892005000600005
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发表时间：
2005-07-01
影响因子：
2.6
通讯作者：
Méndez, F
中科院分区：
文献类型：
--
作者：
Moyano, M;Méndez, F
目标。目的：测定哥伦比亚太平洋沿海地区人群中某些红细胞缺陷的患病率，并评价其与疟原虫密度的关系。这项流行病学研究是对242名在哥伦比亚布埃纳文图拉市热带病诊断中心就诊的恶性疟原虫疟疾患者进行的。测量了寄生虫血症水平，并确定了先天性红细胞缺陷（葡萄糖-6-磷酸脱氢酶（G6PD）缺乏、血红蛋白异常和地中海贫血）和其他可能与寄生虫血症水平相关的因素的存在。红细胞缺陷的发生率为26.4%(95%可信区间21.0%-32.5%)，这与以前在哥伦比亚同一地区的研究结果相似。在多元回归模型中，镰状细胞性贫血或G6PD完全缺乏的个体比没有红细胞缺陷的个体寄生虫病密度低。在对其他相关变量进行校正后，镰状细胞性贫血患者（优势比= 0.30）和G6PD完全缺乏的个体（优势比= 0.72）发生高寄生虫的风险较低。我们的研究结果证实，在哥伦比亚太平洋沿岸地区，红细胞缺陷的高发率与西非一些人群的种族特征相似。我们的研究结果也支持了血红蛋白AS携带者和G6PD缺乏症患者对疟疾的先天抗性的存在。
Objectives. To determine the prevalence of some erythrocyte defects and to evaluate the relation that that has with parasitemia density in individuals diagnosed with Plasmodium falciparum malaria in a population in the Pacific coastal region of Colombia.Methods. This prevalence study was carried out with 242 persons with P. falciparum malaria who had gone for consultation at the Program of Tropical Diseases diagnostic center in the city of Buenaventura, Colombia. The parasitemia levels were measured, and also determined was the presence of congenital erythrocyte defects (glucose-6-phosphate dehydrogenase (G6PD) deficiency, abnormal haemoglobins, and thalassemias) and of other factors possibly related to parasitemia levels.Results. The prevalence of erythrocyte defects was 26.4% (95% confidence interval, 21.0%-32.5%), which was similar to what had been found in previous studies in the same area of Colombia. In the multiple regression models, individuals with sickle cell anemia or a complete deficiency of G6PD had a lower density of parasitemia than did persons without any erythrocyte defect. After adjusting for other variables of interest, the risk of high parasitemias was lower in persons with sickle cell anemia (odds ratio = 0.30) and individuals with a complete deficiency of G6PD (odds ratio = 0.72).Conclusions. Our results confirm the high prevalence of erythrocyte defects in Colombia's Pacific coastal region, in a population with ethnic characteristics that are similar to those of some populations in West Africa. Our results also lend support for the existence of innate resistance to malaria among carriers of hemoglobin AS and in persons with G6PD deficiency.