HISTIOTYPIC ORGANIZATION OF HYPERTROPHIC SCAR IN HUMANS
HISTIOTYPIC ORGANIZATION OF HYPERTROPHIC SCAR IN HUMANS
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DOI：
10.1111/1523-1747.ep12627386
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发表时间：
1972-01-01
影响因子：
6.5
通讯作者：
DOBRKOVSKY, M
中科院分区：
文献类型：
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作者：
LINARES, HA;KISCHER, CW;DOBRKOVSKY, M
增生性瘢痕、增生性和非增生性愈合的成熟瘢痕以及正常皮肤已经通过活检进行了检查，并研究了与每个病例一致的组织学模式。在压力下，胶原蛋白反射出之前被掩盖的正交层图案。增生性瘢痕的特征可能在于胶原蛋白的一致模式，这在成熟瘢痕的正常皮肤中从未发现。这种模式与肥大的最活跃阶段一致，含有胶原结节。它们非常紧凑，通常在其外围有一个胶囊状的带。在周围经常可以观察到血管，早期增生性瘢痕表现为成束或成束的曲线状，其中几个呈螺旋状排列。轮状排列是否继续形成结节或绕过这一阶段而开始成熟取决于未知因素。电子显微镜下，结节内可见高度星状的成纤维细胞，粗面内质网扩张，其他细胞器少。胶原纤维的直径约为正常皮肤的一半。我们的结论是，增生性瘢痕涉及形成胶原结节组成的紧密堆积的胶原。结节形成似乎反映了增生性瘢痕形成的最活跃和最严重阶段。
Hypertrophic scars, mature scars from hypertrophic and non-hypertrophic healing, and normal skin have been examined by biopsy and studied for histological patterns consistent with each case.Normal skin presents collagen appearing randomly of oriented and with a marked waviness. Under stress the collagen reflect, a previously masked orthogonal ply pattern. The hypertrophic scar may be characterized by a consistent pattern of collagen, which is never found in normal skin of a mature scar. This pattern, consistent with the most active stage of hypertrophy, contain nodules of collagen. They are highly compact, often with a capsule-like band about their periphery. Blood vessels are frequently observed about the periphery.The early stage ot hypertrophic scarring displays bundles or tracts in curvilinear form, several of which together demonstrate a whorl-like arrangement. Whether or not the whorl arrangements proceed to form a nodule or bypass this stage to begin maturation is dependent on unknown factors.By electron microscopy, the nodule is seen to contain highly stellate fibroblasts with dilated rough endoplasmic reticulum and few other organelles. The diameter of the collagen filaments is about half that observed in normal skin.We conclude that hypertrophic scarring involves the formation of collagenous nodules composed of tightly packed collagen. Nodular formation appears to reflect the most active and the worst phase of hypertrophic scarring.