Vinyl sulfones:: Inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus
Vinyl sulfones:: Inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus
复制标题
DOI：
10.1021/ja0390294
复制
发表时间：
2004-03-24
影响因子：
15
通讯作者：
McCafferty, DG
中科院分区：
文献类型：
--
作者：
Frankel, BA;Bentley, M;McCafferty, DG
Several small molecule vinyl sulfones were found to exhibit irreversible time-dependent inhibition of theStaphylococcus aureussortase SrtA in vitro. A representative of these compounds was shown to impair the ability ofS. aureusbacteria to bind fibronectin-coated surfaces through in vivo inhibition of SrtA-mediated linkage of fibronectin to the cell surface. These data highlight the potential use of small molecule vinyl sulfones as chemotherapeutics to prevent adhesion to and colonization of host tissues duringS. aureusinfection.
