Pre- and posthatch development of goblet cells in the broiler small intestine: Effect of delayed access to feed
Pre- and posthatch development of goblet cells in the broiler small intestine: Effect of delayed access to feed
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DOI：
10.1093/ps/82.2.320
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发表时间：
2003-02-01
期刊：
影响因子：
4.4
通讯作者：
Sklan, D
中科院分区：
文献类型：
--
作者：
Uni, Z;Smirnov, A;Sklan, D
粘蛋白糖蛋白在胃肠道上皮的正常功能中发挥着关键作用，在这项研究中，在肉鸡中检查了粘蛋白产生细胞的个体发生和发育。孵化前3天开始在小肠中观察到产生粘蛋白的细胞，此时仅含有酸性粘蛋白。孵化后直至孵化后第 7 天，小肠的近端、中段和远端段含有相似比例的产生酸性和中性粘蛋白的杯状细胞。观察到杯状细胞密度梯度沿十二指肠至回肠轴增加。孵化后延迟 48 小时采食导致肠道细胞内粘蛋白增加，这可能是由于粘蛋白分泌受损或粘蛋白产量增加所致。粘蛋白动力学的变化可能会影响小肠的吸收和保护功能。
Mucin glycoproteins play a key role in the regular function of the epithelium of the gastrointestinal tract, and in this study, the ontogenesis and development of mucin producing cells was examined in the broiler. Mucin-producing cells were observed in the small intestine from 3 d before hatch, and at this time contained only acidic mucin. After hatch and until Day 7 posthatch, the proximal, middle, and distal segments of the small intestine contained similar proportions of goblet cells producing acidic and neutral mucins. A gradient of goblet cell density was observed increasing along the duodenal to ileal axis. Delayed access to feed for 48 h posthatch resulted in an increase in intestinal intracellular mucins, which might have been due to impaired mucin secretion or enhanced mucin production. Changes in mucin dynamics could affect absorptive and protective functions of the small intestine.