Post-exposure HIV prophylaxis following sexual exposure: a retrospective audit against recent draft BASHH guidance
Post-exposure HIV prophylaxis following sexual exposure: a retrospective audit against recent draft BASHH guidance
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DOI：
10.1136/sti.2005.017764
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发表时间：
2006-06-01
影响因子：
3.6
通讯作者：
Kulasegaram, R.
中科院分区：
文献类型：
--
作者：
Day, S.;Mears, A.;Kulasegaram, R.
目的：根据英国性健康协会和 HIV 2004 年指南草案，回顾性审核性暴露后 HIV 预防 (PEPSE) 的管理。方法：对 2000 年 1 月至 2004 年 11 月的病例记录进行回顾性审查。研究期间，该指南草案并未应用于临床实践。结果：76 名患者接受了 PEPSE。 79%（95% CI 68.08 至 87.46）的 PEPSE 处方的暴露量符合指南推荐的适应症（目标 90%）。 87%（95% CI 77.13 至 93.51）的 PEPSE 在风险暴露后 72 小时内服用（目标 90%）。 91%（95% CI 81.94 至 96.22）的接受者接受了推荐的抗逆转录病毒组合治疗。 53%（95% CI 40.84 至 64.21）的接受者完成了 PEPSE 课程（目标 75%）。 45% 的患者参加了 3 个月的 HIV 后续检测，但只有 12%（95% CI 5.56 至 21.29）参加了 3 个月和 6 个月的 HIV 检测（目标 75%）。 结论：PEPSE 主要用于推荐适应症，并在风险暴露后 72 小时内配药。艾滋病毒暴露后 3 个月和 6 个月的 PEPSE 完成率和出勤率需要提高，或许可以通过引入 PEPSE 诊所来提高。
Objectives: To retrospectively audit the management of post-exposure HIV prophylaxis following sexual exposure (PEPSE) against the British Association for Sexual Health and HIV 2004 draft guidance.Methods: A retrospective review of case notes from January 2000 to November 2004. The draft guidelines were not adopted into clinical practice during the study period.Results: 76 patients received PEPSE. 79% (95% CI 68.08 to 87.46) of PEPSE prescriptions were given for exposures that were in accordance with the guidelines' recommended indications (target 90%). 87% (95% CI 77.13 to 93.51) of PEPSE was prescribed within 72 hours of risk exposure (target 90%). 91% (95% CI 81.94 to 96.22) of recipients received a recommended antiretroviral combination. 53% (95% CI 40.84 to 64.21) of recipients completed the PEPSE course (target 75%). 45% of patients attended for the 3 month follow up HIV test but only 12% (95% CI 5.56 to 21.29) attended for both the 3 month and 6 month HIV test (target 75%).Conclusion: PEPSE is predominantly being prescribed for recommended indications and is dispensed within 72 hours of risk exposure. PEPSE completion rates and attendance for 3 months and 6 months post-exposure HIV testing need improving, perhaps by introducing a PEPSE clinic.