PARITY AND HEPATOCELLULAR-CARCINOMA - A POPULATION-BASED STUDY IN SWEDEN
PARITY AND HEPATOCELLULAR-CARCINOMA - A POPULATION-BASED STUDY IN SWEDEN
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DOI：
10.1002/ijc.2910550508
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发表时间：
1993-11-11
影响因子：
6.4
通讯作者：
PAVIA, M
中科院分区：
文献类型：
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作者：
LAMBE, M;TRICHOPOULOS, D;PAVIA, M
胎次与肝细胞癌（HCC）之间的关系是通过连接2个瑞典全国性登记处生成的数据库进行研究的；癌症登记处和生育登记处。在1925年至1960年出生的女性中，1958年至1984年癌症登记处记录的133例HCC患者与665例年龄匹配的对照组进行了比较。在这个嵌套的病例对照研究中，胎次、第一胎年龄或双胞胎频率与HCC风险之间没有正相关。先前报道的胎次与HCC之间的正相关似乎仅限于慢性乙型肝炎病毒感染引起的HCC病例；这些病例仅占瑞典HCC病例的一小部分。(C) 1993 Wiley-Liss, Inc。
The association between parity and hepatocellular carcinoma (HCC) was studied using a data-base generated by linking 2 Swedish nation-wide registries; the Cancer Registry and the Fertility Registry. Among women born between 1925 and 1960, 133 patients with HCC recorded in the Cancer Registry between 1958 and 1984 were compared with 665 age-matched controls. In this nested case-control study there was no positive association between parity, age at first birth or frequency of twinning on the one hand, and risk of HCC on the other. It appears that the positive association between parity and HCC previously reported is limited to cases of HCC caused by chronic infection with hepatitis B virus; these cases represent only a small fraction of HCC cases in Sweden. (C) 1993 Wiley-Liss, Inc.