Initial heritability analyses of endophenotypic measures for schizophrenia - The consortium on the genetics of schizophrenia
Initial heritability analyses of endophenotypic measures for schizophrenia - The consortium on the genetics of schizophrenia
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DOI：
10.1001/archpsyc.64.11.1242
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发表时间：
2007-11-01
影响因子：
--
通讯作者：
Schork, Nicholas J.
中科院分区：
文献类型：
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作者：
Greenwood, Tiffany A.;Braff, David L.;Schork, Nicholas J.
内容：探索特定内表型的遗传结构可能是了解精神分裂症遗传基础的有力策略。目的：描述根据精神分裂症遗传性而选择的一些关键内表型指标的遗传结构。设计：基于家庭的遗传性研究。设置：美国各地的七个地点。参与者：在这些初始数据分析的时候，通过先证者确定的183个核心家庭的成员已经评估了这些内在表型。方差分量模型被用来评估的遗传力和环境和遗传的相关性之间的内表型。精神分裂症遗传学联合会评估了听觉惊吓的前脉冲抑制、P50事件相关电位抑制、眼球运动的反跳跃任务和连续性能测试的神经认知测量的神经生理学测量（降级刺激版本），加州语言学习测试，字母-数字排序测试，和宾夕法尼亚大学计算机神经认知成套测验的6项测量。结果：所有的内表型和宾夕法尼亚大学计算机神经认知成套测验的测量结果均具有显著的遗传性（P
Context: Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia.Objective: To characterize the genetic architecture of some key endophenotypic measures selected for their reported heritabilities in schizophrenia.Design: Family-based heritability study.Setting: Seven sites across the United States.Participants: At the time of these initial data analyses, the members of 183 nuclear families ascertained through probands with schizophrenia had been assessed for these endophenotypes.Main Outcome Measures: Variance component models were used to assess the heritability of and the environmental and genetic correlations among the endophenotypes. The Consortium on the Genetics of Schizophrenia assesses the neurophysiologic measures of prepulse inhibition of acoustic startle, P50 event-related potential suppression, and the antisaccade task for eye movements and the neurocognitive measures of the Continuous Performance Test (Degraded Stimulus version), the California Verbal Learning Test, the Letter-Number Sequencing test, and 6 measures from the University of Pennsylvania Computerized Neurocognitive Battery. The heritabilities of these 12 measures are the focus of this article.Results: All of the endophenotypes and the University of Pennsylvania Computerized Neurocognitive Battery measures were found to be significantly heritable (P