The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis
The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis
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DOI：
10.1177/1352458506071162
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发表时间：
2007-01-01
影响因子：
5.8
通讯作者：
Beaumont, J. G.
中科院分区：
文献类型：
--
作者：
Bailey, A.;Channon, S.;Beaumont, J. G.
本研究检查了晚期多发性硬化症患者和匹配的健康对照参与者的认知表现和主观疲劳评级。在一次测试的开始和结束时执行一项涉及注意力（0-back）的连续 n-back 任务；在另一个测试会话的开始和结束时执行涉及工作记忆的任务（1-back）。在每次训练期间定期对主观疲劳进行评级。总体而言，根据训练期间 n-back 表现的变化进行评估，MS 组客观认知疲劳的证据有限。在 1-back 测试期间，MS 组的主观疲劳水平确实比对照组有更大的增加，但主观疲劳的变化与认知表现的变化没有显着相关。讨论了这些发现对我们理解多发性硬化症认知疲劳的影响。
The present study examined the cognitive performance and ratings of subjective fatigue in people with advanced MS and matched healthy control participants. A continuous n-back task, involving attention (0-back), was performed at the beginning and end of one testing session; a task involving working memory (1-back) was performed at the beginning and end of another testing session. Subjective fatigue was rated at regular intervals during each session. Overall, there was limited evidence of objective cognitive fatigue in the MS group, as assessed by the change in n-back performance during the sessions. The MS group did report a greater increase, than the control group, in the level of subjective fatigue during the 1-back testing session, but change in subjective fatigue did not correlate significantly with change in cognitive performance. The implications of these findings for our understanding of cognitive fatigue in MS are discussed.