Nanocrystalline hydroxyapatite for bone repair: an animal study
Nanocrystalline hydroxyapatite for bone repair: an animal study
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DOI：
10.1007/s10856-009-3859-1
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发表时间：
2010-01-01
影响因子：
3.7
通讯作者：
Schulz, M.
中科院分区：
文献类型：
--
作者：
Brandt, J.;Henning, S.;Schulz, M.
羟基磷灰石已成为最常用的替代骨或引导骨再生的材料。纳米羟基磷灰石悬浮液由于其晶体尺寸小，可以改善吸收，近年来被引入临床应用。我们在兔模型中研究了纳米晶羟基磷灰石Ostim（A（R））的吸收和骨整合。将材料单独或与自体或同种异体骨组合植入兔股骨远端。术后2、4、6、8、12周分别进行光镜和电镜观察。我们观察到直接骨接触以及软组织内含物。但我们可以观察到，在绝大多数种植体中，没有或只有边缘性的腐烂，也没有明显的吸收。在原位，纳米晶材料主要形成密集堆积的团聚体，这些团聚体一旦包含在骨或结缔组织中就被保存下来。严重的副作用是在远离植入部位的股骨中开始骨质溶解，导致皮质骨中的广泛缺损。
Hydroxyapatite has become the most common material to replace bone or to guide its regeneration. Nanocrystalline hydroxyapatite suspension had been introduced in the clinical use recently under the assumption that small dimension of crystals could improve resorption. We studied the resorption and osteointegration of the nanocrystalline hydroxyapatite Ostim(A (R)) in a rabbit model. The material was implanted either alone or in combination with autogenic or allogenic bone into distal rabbit femora. After survival time of 2, 4, 6, 8 and 12 weeks the implants had been evaluated by light and electron microscopy. We observed a direct bone contact as well as inclusion into soft tissue. But we could observe no or only marginal decay and no remarkable resorption in the vast majority of implants. In situ the nanocrystalline material mostly formed densely packed agglomerates which were preserved once included in bone or connective tissue. A serious side effect was the initiation of osteolysis in the femora far from the implantation site causing extended defects in the cortical bone.