BREAST STIMULATION IN CYCLING WOMEN, PREGNANT-WOMEN AND A WOMAN WITH INDUCED LACTATION - PATTERN OF RELEASE OF OXYTOCIN, PROLACTIN AND LUTEINIZING-HORMONE
BREAST STIMULATION IN CYCLING WOMEN, PREGNANT-WOMEN AND A WOMAN WITH INDUCED LACTATION - PATTERN OF RELEASE OF OXYTOCIN, PROLACTIN AND LUTEINIZING-HORMONE
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DOI：
10.1111/j.1365-2265.1986.tb01670.x
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发表时间：
1986-08-01
影响因子：
3.2
通讯作者：
FINLEY, BE
中科院分区：
文献类型：
--
作者：
AMICO, JA;FINLEY, BE
对5名正常骑自行车妇女和19名妊娠晚期妇女在间歇性机械泵和触觉刺激乳房前和过程中抽取血浆，测定催产素（OT）和PRL水平。OT显着增加高于基线，在两个五骑自行车的妇女和PRL增加的两个OT响应者的乳房刺激。在孕妇中，乳头刺激后的平均OT显着高于乳头刺激前，而PRL没有显着增加。OT乳头刺激的反应发生在18 19名孕妇相比，只有两个正常的骑自行车的妇女，但在孕妇的OT反应的幅度小于骑自行车的妇女或产后哺乳期妇女先前在本实验室研究。在一个非产后妇女谁诱导哺乳的目的母乳喂养的婴儿，OT和PRL进行了测量之前和期间的机械泵和触觉刺激开始母乳喂养。OT增加机械泵和触觉刺激的乳房，以及吸吮，而PRL增加，只有在响应吸吮。在以下时间每20分钟测量一次血浆LH水平，持续160分钟：开始母乳喂养前，母乳喂养时诱导泌乳期间和停止母乳喂养后30天。尽管在母乳喂养期间月经过少的发展，孕激素水平没有受到抑制，LH以正常的脉动方式释放。
Levels of oxytocin (OT) and PRL were measured in plasma drawn before and during intermittent mechanical pump and tactile stimulation of the breast in five normal cycling women and 19 women in the third trimester of pregnancy. OT was significantly increased above baseline in response to breast stimulation in two of five cycling women and PRL increased in one of the two OT responders. In pregnant women, mean OT post nipple stimulation was significantly higher than pre nipple stimulation whereas PRL did not increase significantly. The response of OT to nipple stimulation occurred in 18 of 19 pregnant women compared to only two of five normal cycling women but the magnitude of the OT response in pregnant women was less than in cycling women or post-partum lactating women previously studied in this laboratory. In one non post-partum woman who induced lactation for the purpose of breast-feeding an adopted infant, OT and PRL were measured before and during mechanical pump and tactile stimulation before initiation of breast-feeding. OT increased during mechanical pump and tactile stimulation of the breast, as well as suckling, whereas PRL increased only in response to suckling. Levels of LH were measured in plasma every 20 min for 160 min at the following times: before initiation of breast-feeding, during induced lactation while breast-feeding, and 30 d after discontinuation of breast-feeding. Despite the development of oligomenorrhoea during the period of breast-feeding, levels of progesterone were not suppressed and LH was released in a normal pulsatile fashion.