Mechanosensing Piezo channels in gastrointestinal disorders.
Mechanosensing Piezo channels in gastrointestinal disorders.
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胃肠道疾病中的机械感应压电通道
DOI：
10.1172/jci171955
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发表时间：
2023-10-02
影响因子：
15.9
通讯作者：
Liddle, Rodger A.
中科院分区：
文献类型：
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作者：
Swain, Sandip M.;Liddle, Rodger A.
身体的所有细胞都受到拉力、压缩力、重力、剪应力或压力等物理力的作用。细胞将这些机械信号转化为细胞内的生化信号；这个过程是所有细胞的固有特性，是许多细胞功能所必需的。细胞对力的反应能力很大程度上取决于细胞表面表达的机械离子通道阵列。机械感觉的改变会损害有意识的感觉，如触觉和听觉，以及无意识的感觉，如血压调节和胃肠道（GI）活动。胃肠道感知压力变化和机械力的能力对调节运动至关重要，但它也是胃肠道疼痛的基础。最近在肠道中发现的机械激活离子通道Piezo1和Piezo2以及异常离子通道调节对细胞功能的影响表明，这些通道可能在疾病中起致病作用。在这里，我们讨论了我们目前对机械激活的压电通道在胰腺和胃肠道疾病发病机制中的理解，包括胰腺炎、糖尿病、肠易激综合征、胃肠道肿瘤和炎症性肠病。我们还描述了压电通道如何成为治疗胃肠道疾病的重要靶点。
All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mechanical cues into intracellular biochemical signals; this process is an inherent property of all cells and is essential for numerous cellular functions. A cell’s ability to respond to force largely depends on the array of mechanical ion channels expressed on the cell surface. Altered mechanosensing impairs conscious senses, such as touch and hearing, and unconscious senses, like blood pressure regulation and gastrointestinal (GI) activity. The GI tract’s ability to sense pressure changes and mechanical force is essential for regulating motility, but it also underlies pain originating in the GI tract. Recent identification of the mechanically activated ion channels Piezo1 and Piezo2 in the gut and the effects of abnormal ion channel regulation on cellular function indicate that these channels may play a pathogenic role in disease. Here, we discuss our current understanding of mechanically activated Piezo channels in the pathogenesis of pancreatic and GI diseases, including pancreatitis, diabetes mellitus, irritable bowel syndrome, GI tumors, and inflammatory bowel disease. We also describe how Piezo channels could be important targets for treating GI diseases.
心脏力学中的机械生物学。
影响因子：
--
作者：
Sheetz M
通讯作者：
Sheetz M