TRANSFER-RNA GENES - LANDMARKS FOR INTEGRATION OF MOBILE GENETIC ELEMENTS IN DICTYOSTELIUM-DISCOIDEUM
TRANSFER-RNA GENES - LANDMARKS FOR INTEGRATION OF MOBILE GENETIC ELEMENTS IN DICTYOSTELIUM-DISCOIDEUM
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DOI：
10.1126/science.2567533
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发表时间：
1989-06-23
期刊：
影响因子：
56.9
通讯作者：
DINGERMANN, T
中科院分区：
文献类型：
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作者：
MARSCHALEK, R;BRECHNER, T;DINGERMANN, T
在原核生物和真核生物中，可移动的遗传元件经常破坏负责存储遗传信息的高度保守的染色体结构。决定整合这些要素的地点的因素仍然未知。转移RNA(TRNA)基因与盘基网柄菌细胞黏液霉菌中不同可能的可移动遗传元件有非常显著的相关性。这些结果表明，盘状芽孢杆菌中的tRNA基因，以及可能在低等真核生物中普遍存在的tRNA基因，可能是以严格位置特异的方式整合不同转座元件的基因组标志。
In prokaryotes and eukaryotes mobile genetic elements frequently disrupt the highly conservative structures of chromosomes, which are responsible for storage of genetic information. The factors determining the site for integration of such elements are still unknown. Transfer RNA (tRNA) genes are associated in a highly significant manner with different putative mobile genetic elements in the cellular slime mold Dictyostelium discoideum. These results suggest that tRNA genes in D. discoideum, and probably tRNA genes generally in lower eukaryotes, may function as genomic landmarks for the integration of different transposable elements in a strictly position-specific manner.